157341-41-8

中文名称 (2S)-N-[(1R)-1-(1,3-苯并二氧戊环-5-基)丁基]-3,3-二乙基-2-[4-[(4-甲基-1-哌嗪基)羰基]苯氧基]-4-氧代-1-氮杂环丁烷甲酰胺

英文名称 DMP 777

CAS 157341-41-8

分子式 C31H40N4O6

分子量 564.67

MOL 文件 157341-41-8.mol

更新日期 2024/11/15 18:20:30

157341-41-8 结构式

基本信息物理化学性质 DMP 777价格(试剂级) 常见问题列表

基本信息

中文别名

(2S)-N-[(1R)-1-(1,3-苯并二氧戊环-5-基)丁基]-3,3-二乙基-2-[4-[(4-甲基-1-哌嗪基)羰基]苯氧基]-4-氧代-1-氮杂环丁烷甲酰胺

英文别名

DMP 777
L 694458
L-694458
DMP-777
DMP777
(S)-N-((R)-1-(Benzo[d][1,3]dioxol-5-yl)butyl)-3,3-diethyl-2-(4-(4methyl-piperazine-1-carbonyl)
(S)-N-((R)-1-(Benzo[d][1,3]dioxol-5-yl)butyl)-3,3-diethyl-2-(4-(4methyl-piperazine-1-carbonyl)phe
(S)-N-((R)-1-(Benzo[d][1,3]dioxol-5-yl)butyl)-3,3-diethyl-2-(4-(4-Methylpiperazine-1-carbonyl)phenoxy)-4-oxoazetidine-1-carboxaMide
(2S)-N-[(1R)-1-(1,3-Benzodioxol-5-yl)butyl]-3,3-diethyl-2-[4-[(4-methyl-1-piperazinyl)carbonyl]phenoxy]-4-oxo-1-azetidinecarboxamide
1-AzetidinecarboxaMide,N-[(1R)-1-(1,3-benzodioxol-5-yl)butyl]-3,3-diethyl-2-[4-[(4-Methyl-1-piperazinyl)carbonyl]phenoxy]-4-oxo-,(2S)-
(S)-N-((R)-1-(Benzo[d][1,3]dioxol-5-yl)butyl)-3,3-diethyl-2-(4-(4methyl-piperazine-1-carbonyl)phenoxy)-4-oxoazetidine-1-carboxamide (3.5% w/w solution)

所属类别

生物化工：激动剂抑制剂

物理化学性质

密度1.227

储存条件-20°C储存

溶解度DMSO : 38.33 mg/mL (67.88 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)

酸度系数(pKa)pKa 7.04(H2O tunde?ned Iunde?ned) (Uncertain)

形态粉末

颜色White to yellow

DMP 777价格(试剂级)

报价日期	产品编号	产品名称	CAS号	包装	价格
2025/05/22	HY-75957	DMP 777	157341-41-8	1 mg	681元
2025/05/22	HY-75957	(2S)-N-[(1R)-1-(1,3-苯并二氧戊环-5-基)丁基]-3,3-二乙基-2-[4-[(4-甲基-1-哌嗪基)羰基]苯氧基]-4-氧代-1-氮杂环丁烷甲酰胺 DMP 777	157341-41-8	5mg	1500元
2025/05/22	HY-75957	(2S)-N-[(1R)-1-(1,3-苯并二氧戊环-5-基)丁基]-3,3-二乙基-2-[4-[(4-甲基-1-哌嗪基)羰基]苯氧基]-4-氧代-1-氮杂环丁烷甲酰胺 DMP 777	157341-41-8	10mM * 1mLin DMSO	1863元

常见问题列表

生物活性

DMP 777 是一种有效的，选择性的，可口服的 human leukocyte elastase (HLE) 抑制剂。

靶点

Human leukocyte elastase (HLE)

体内研究

DMP-777-treated rats show a marked decrease in H/K-ATPase staining parietal cells. DMP-777-induced loss of parietal cells is significantly ameliorated with coadministration of omeprazole. DMP-777-treated animals demonstrates marked foveolar hyperplasia in the fundus with prominent expansion of diastase-resistant, PAS-positive surface mucous cells. When DMP-777 is coadministeredwith omprazole, there is a significant decrease in BrdUpositive S-phase cells compared with rats thatreceive DMP-777 alone. After oral dosing of monkeys at 40 mg/kg with DMP-777 the only stereoisomer detected in the post-dose plasma samples is the starting material DMP-777, and no inversion of the configuration at positions 'a' and 'b' of DMP-777 has occurred in vivo. Mist1-/- mice treated with DMP-777 show fewer chief cell to SPEM transitions. Mist1-/- mice treated with L635 demonstrates significantly fewer proliferative SPEM cells compared to control mice.