158205-05-1

中文名称 158205-05-1

英文名称 L-745337

CAS 158205-05-1

分子式 C16H13F2NO3S2

分子量 369.41

MOL 文件 158205-05-1.mol

158205-05-1 结构式

基本信息物理化学性质常见问题列表

基本信息

中文别名

化合物 T15687

英文别名

L-745337
Thioflosulide
Methanesulfonamide, N-[6-[(2,4-difluorophenyl)thio]-2,3-dihydro-1-oxo-1H-inden-5-yl]-

物理化学性质

沸点495.8±55.0 °C(Predicted)

密度1.52±0.1 g/cm3(Predicted)

储存条件-20°C储存

溶解度溶于二甲基亚砜

酸度系数(pKa)6?+-.0.20(Predicted)

常见问题列表

生物活性

Thioflosulide (L-745337) 是一种选择性的 COX2 抑制剂，IC50 值为 2.3 nM，具有抗炎功效。

靶点

COX-2

2.3 nM (IC ₅₀ )

体内研究

In a rat model of postoperative pain, Thioflosulide (L-745337) (40-80 μg, intrathecal) coadministered with intrathecal morphine (0.5 nmol) increases the withdrawal thresholds in a dose-dependent manner. Adding 80 μg Thioflosulide (L-745337) to 1 nmol morphine produces an antiallodynic effect greater than that of morphine at twice the dose. Thioflosulide (L-745337) (0-30 mg/kg, s.c.) combined with intrathecal morphine results in the same antiallodynic response as morphine alone. Thioflosulide (L-745337) shows anti-inflammatory activity, with the effective-dose of 0.4 mg/kg, and the maximal anti-inflammation dose of 5 mg/kg in arthritic rats.