161416-61-1
中文名称
Pyridine, 2-methyl-3-[(2S)-2-pyrrolidinylmethoxy]-, dihydrochloride
英文名称
Pyridine, 2-methyl-3-[(2S)-2-pyrrolidinylmethoxy]-, dihydrochloride
CAS
161416-61-1
分子式
C11H16N2O.2ClH
分子量
265.179
MOL 文件
161416-61-1.mol
更新日期
2023/03/20 15:41:23
161416-61-1 结构式
基本信息
中文别名
POZANICLINE DIHYDROCHLORIDE 英文别名
ABT 089 dihydrochloridePozanicline dihydrochloride
ABT 089 dihydrochloride (ABT089
2-Methyl-3-[(2S)-pyrrolidinylmethoxy]pyridine dihydrochloride
Pyridine, 2-methyl-3-[(2S)-2-pyrrolidinylmethoxy]-, dihydrochloride
Pyridine, 2-methyl-3-[(2S)-2-pyrrolidinylmethoxy]-, dihydrochloride价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/05/22 | HY-110160 | Pozanicline dihydrochloride | 161416-61-1 | 1 mg | 571元 |
| 2025/05/22 | HY-110160 | Pyridine, 2-methyl-3-[(2S)-2-pyrrolidinylmethoxy]-, dihydrochloride Pozanicline dihydrochloride | 161416-61-1 | 5mg | 1500元 |
| 2025/05/22 | HY-110160 | Pyridine, 2-methyl-3-[(2S)-2-pyrrolidinylmethoxy]-, dihydrochloride Pozanicline dihydrochloride | 161416-61-1 | 10mg | 2400元 |
常见问题列表
生物活性
Pozanicline dihydrochloride (ABT-089 dihydrochloride) 是一种具有口服活性的烟碱型乙酰胆碱受体 (nAChR) 激动剂，与 [3H] 胱氨酸位点结合，Ki 为 16.7 nM。Pozanicline dihydrochloride 是一种 α4β2 选择性 nAChR 激动剂，与大鼠脑 α4β2 nAChR 结合，Ki 为 17 nM，而与 α7nAChR 的结合力很弱。体外研究
Pozanicline (ABT-089) is a partial agonist at α4β2 nAChR. Moreover, one α6β2 nAChR subtype is particularly sensitive to Pozanicline with an EC
50
of 0.11 μM.
Pozanicline (ABT-089) shows high selectivity for α6β2 and α4α5β2 nAChR subtypes.
体内研究
Pozanicline (ABT-089; 0.3 mg/kg and 0.6 mg/kg) reverses nicotine withdrawal-induced deficits in contextual fear conditioning.
| Animal Model: | Adult male C57BL6/J mice at 8-12 weeks of age. |
| Dosage: | 0.3 mg/kg and 0.6 mg/kg |
| Administration: | Treated 5 min before training and testing for contextual fear conditioning |
| Result: | A dose of 0.3 mg/kg and 0.6 mg/kg ameliorated nicotine withdrawal-induced cognitive deficits in contextual fear conditioning. |