1621585-17-8

中文名称 Pyrano[3,4-d][1,3]thiazin-2-amine, 8a-(2,4-difluorophenyl)-4,4a,5,6,8,8a-hexahydro-4-methyl-6-(3-methyl-5-isoxazolyl)-, (4R,4aR,6R,8aS)-

英文名称 Pyrano[3,4-d][1,3]thiazin-2-amine, 8a-(2,4-difluorophenyl)-4,4a,5,6,8,8a-hexahydro-4-methyl-6-(3-methyl-5-isoxazolyl)-, (4R,4aR,6R,8aS)-

CAS 1621585-17-8

分子式 C18H19F2N3O2S

分子量 379.42

MOL 文件 1621585-17-8.mol

1621585-17-8 结构式

基本信息物理化学性质应用领域安全数据

基本信息

中文别名

化合物 T28390

英文别名

PF9238
PF-9238
PF 9238
PF-06649283 >=98% (HPLC)
Pyrano[3,4-d][1,3]thiazin-2-amine, 8a-(2,4-difluorophenyl)-4,4a,5,6,8,8a-hexahydro-4-methyl-6-(3-methyl-5-isoxazolyl)-, (4R,4aR,6R,8aS)-

物理化学性质

沸点535.7±60.0 °C(Predicted)

密度1.50±0.1 g/cm3(Predicted)

储存条件2-8°C

溶解度DMSO: 10mg/mL, clear

酸度系数(pKa)4.24±0.70(Predicted)

形态powder

颜色white to beige

InChI1S/C18H19F2N3O2S/c1-9-5-16(25-23-9)15-7-13-10(2)26-17(21)22-18(13,8-24-15)12-4-3-11(19)6-14(12)20/h3-6,10,13,15H,7-8H2,1-2H3,(H2,21,22)/t10-,13+,15-,18-/m1/s1

InChIKeyHVEVDFRWOQHAPJ-CKMNQQOVSA-N

SMILESC[C@@H]1[C@@]2([H])[C@@](CO[C@@H](C3=CC(C)=NO3)C2)(C4=CC=C(F)C=C4F)N=C(N)S1

应用领域

用途一

PF9238 is a beta-secretase I inhibitor. Treatment with PF9238 results in the accumulation of autofluorescent granules in the retinas. PF9238 has a CatD potency of 12 uM in vivo.

安全数据

WGK GermanyWGK 3

存储类别11 - Combustible Solids

危险性类别Eye Irrit. 2
Skin Irrit. 2
STOT SE 3