1623194-37-5
1623194-37-5 结构式
基本信息
中文别名
化合物 T13550 英文别名
2H-1-Benzopyran-7-propanoic acid, β-cyclopropyl-2-[2-fluoro-4-(2-methoxy-4-pyridinyl)phenyl]-3,4-dihydro-α-methyl-, (αS,βR,2S)-物理化学性质
沸点596.7±50.0 °C(Predicted)
密度1.262±0.06 g/cm3(Predicted)
储存条件-20°C储存
溶解度溶于二甲基亚砜
酸度系数(pKa)4.63±0.11(Predicted)
常见问题列表
生物活性
AP5 是一种有效的选择性 GPR40 受体激动剂，在大鼠 hIP1 实验中，AP5 作用于 GPR40 受体，EC50 为 0.49±0.28 nM。靶点
EC50: 0.49±0.28 nM (GPR40 Receptor)
体外研究
AP5 is a potent and selective GPR40 AgoPAM that demonstrates excellent in vivo efficacy. In the GK rat oral glucose tolerance test (oGTT), oral administration of AP5 1 h before an oral dextrose challenge shows that AP5 significantly reduces blood glucose levels compared to the vehicle. AP5 is determined to be more efficacious in this model, demonstrating maximally efficacious glucose lowering at a plasma concentration of 4.9 μM at 10 mg/kg.