163655-37-6

中文名称 CS-2885

英文名称 MAZ51

CAS 163655-37-6

分子式 C21H18N2O

分子量 314.38

MOL 文件 163655-37-6.mol

更新日期 2026/02/13 08:39:37

163655-37-6 结构式

基本信息物理化学性质安全数据图谱信息 CS-2885价格(试剂级) 常见问题列表

基本信息

中文别名

化合物MAZ51
3-((4-(二甲基氨基)萘-1-基)亚甲基)吲哚啉-2-酮

英文别名

MAZ51
CS-2885
MAZ51
MAZ-51
MAZ 51
VEGFR3 Kinase Inhibitor, MAZ
3-(4-DIMETHYLAMINO-NAPHTHALEN-1-YLMETHYLENE)-1,3-DIHYDRO-INDOL-2-ONE
(3E)-3-[[4-(dimethylamino)naphthalen-1-yl]methylidene]-1H-indol-2-one
(3E)-3-{[4-(Dimethylamino)-1-naphthyl]methylene}-1,3-dihydro-2H-indol-2-one
2H-Indol-2-one, 3-[[4-(dimethylamino)-1-naphthalenyl]methylene]-1,3-dihydro-

物理化学性质

储存条件2-8°C

溶解度DMSO: 11 mg/mL

形态solid

颜色orange

InChI1S/C21H18N2O/c1-23(2)20-12-11-14(15-7-3-4-9-17(15)20)13-18-16-8-5-6-10-19(16)22-21(18)24/h3-13H,1-2H3,(H,22,24)

InChIKeyVFCXONOPGCDDBQ-UHFFFAOYSA-N

SMILESN1c2c(cccc2)C(=Cc3c4c(c(cc3)N(C)C)cccc4)C1=O

安全数据

危险性符号(GHS) GHS hazard pictograms

GHS07

警示词警告

危险性描述H302-H315-H319-H335

防范说明P261-P280-P301+P312-P302+P352-P305+P351+P338

危险品标志Xn,N

危险类别码22-37/38-41-51/53

安全说明26-39-61

危险品运输编号UN 3077 9/PG 3

WGK GermanyWGK 3

存储类别11 - Combustible Solids

图谱信息

CS-2885(163655-37-6)核磁图(¹HNMR)

CS-2885价格(试剂级)

报价日期	产品编号	产品名称	CAS号	包装	价格
2025/12/22	HY-116624	MAZ51	163655-37-6	1 mg	387元
2025/12/22	HY-116624	MAZ51	163655-37-6	5 mg	968元
2025/12/22	HY-116624	CS-2885 MAZ51	163655-37-6	10mg	1550元

常见问题列表

生物活性

MAZ51 是一种选择性的 vascular endothelial growth factor receptor (VEGFR)-3 (Flt-4) tyrosine kinase 的有效抑制剂。MAZ51 通过 Akt/GSK3β 的磷酸化和 RhoA 的激活来诱导神经胶质瘤细胞的细胞圆缩和G2/M细胞周期停滞。 MAZ51 可抑制多种非VEGFR-3表达肿瘤细胞的增殖并诱导其凋亡。

靶点

Target	Value
VEGFR-3 ()
Akt ()
GSK3β ()
RhoA ()

体外研究

MAZ51 (2.5-10 μM; 24 hours) blocks proliferation and induces apoptosis in a wide variety of tumor cells.
MAZ51 (0.5-50 μM; 25 minutes) has no effect on ligand-induced autophosphorylation of EGFR, IGF-1R and PDGFRβ in A431 cells, HEK-293 cells, and PAE cells, respectively.

Cell Proliferation Assay

Cell Line:	MT450, 1AS, ASM, G, AT6.1, MTLN3, MTLY, NM-081 cells
Concentration:	2.5, 10 μM
Incubation Time:	24 hours
Result:	Induced apoptosis in a wide variety of tumor cells.

Apoptosis Analysis

Cell Line:	MT450, 1AS, ASM, G, AT6.1, MTLN3, MTLY, NM-081 cells
Concentration:	2.5, 10 μM
Incubation Time:	24 hours
Result:	Blocked proliferation in a wide variety of tumor cells.

体内研究

MAZ51 (8 mg/kg; i.p.; daily for 15 day) significantly suppresses the growth of MT450 tumors.

Animal Model:	Wistar Furth rats (bearing MT450 cells)
Dosage:	8 mg/kg
Administration:	Intraperitoneal injection; daily for 15 day
Result:	Significantly suppressed the growth of MT450 tumors.