1638750-96-5
1638750-96-5 结构式
基本信息
ADU-S100 ammonium salt
ML RR-S2 CDA (ammonium salt)
STING-INDUCER-1 AMMONIUM SALT
ML RR-S2 CDA ammonium salt(ADU-S100)
Adenosine, [P(R)]-5'-O-[(R)-hydroxymercaptophosphinyl]-P-thioadenylyl-(2'→5')-, cyclic nucleotide, ammonium salt (1:2)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/02/08 | HY-12885B | ADU-S100铵盐 ADU-S100 ammonium salt | 1638750-96-5 | 1mg | 3300元 |
| 2025/02/08 | HY-12885B | ADU-S100铵盐 ADU-S100 ammonium salt | 1638750-96-5 | 10mM * 1mLin DMSO | 26303元 |
| 2023/03/20 | HY-12885B | ADU-S100铵盐 ADU-S100 ammonium salt | 1638750-96-5 | 5 mg | 12000元 |
常见问题列表
STING
ADU-S100 shows enhanced type I IFN production over CDA in THP-1 human monocytes. In contrast, the dithio, mixed-linkage cyclic dinucleotide (CDN) derivatives (ML RR-CDA, ML RR-S2 CDG, and ML RR-S2 cGAMP) potently activate all five hSTING alleles, including the refractory hSTING REF and hSTING Q alleles. ADU-S100 induces the highest expression of IFN-β and the pro-inflammatory cytokines TNF-α, IL-6, and MCP-1 on a molar equivalent basis, as compared to endogenous ML cGAMP and the TLR3 agonist poly I:C. ADU-S100 is also found to induce aggregation of STING and induce phosphorylation of TBK1 and IRF3 in mouse bone marrow macrophage (BMM). ADU-S100 induces significantly higher levels of IFN-α when compared to ML cGAMP.
ADU-S100 shows higher anti-tumor control than the endogenous ML cGAMP. A dose response of the ADU-S100 compound is performed in B16 tumor-bearing mice, which identifies an optimal antitumor dose level that also elicites maximum tumor antigen-specific CD8 + T cell responses, and improves long-term survival to 50%.