172286-77-0
中文名称
Homocarbonyltopsentin
英文名称
Homocarbonyltopsentin
CAS
172286-77-0
分子式
C21H14N4O3
分子量
370.36
MOL 文件
172286-77-0.mol
172286-77-0 结构式
基本信息
中文别名
化合物 T13723 英文别名
PK4C9Homocarbonyltopsentin
Methanone, [2-[(6-hydroxy-1H-indol-3-yl)carbonyl]-1H-imidazol-4-yl]-1H-indol-3-yl- (9CI)
物理化学性质
熔点>210 °C
沸点801.2±75.0 °C(Predicted)
密度1.539±0.06 g/cm3(Predicted)
储存条件-20°C储存
溶解度DMSO: 125 mg/mL (337.51 mM)
酸度系数(pKa)7.50±0.10(Predicted)
形态Solid
颜色White to yellow
InChI1S/C21H14N4O3/c26-11-5-6-13-15(9-23-17(13)7-11)20(28)21-24-10-18(25-21)19(27)14-8-22-16-4-2-1-3-12(14)16/h1-10,22-23,26H,(H,24,25)
InChIKeyDRCVQVIMGSWRLN-UHFFFAOYSA-N
SMILES[nH]1c(nc(c1)C(=O)c4c5c([nH]c4)cccc5)C(=O)c2c3c([nH]c2)cc(cc3)O
Homocarbonyltopsentin价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/12/22 | HY-117389 | Homocarbonyltopsentin Homocarbonyltopsentin | 172286-77-0 | 5mg | 2200元 |
| 2025/12/22 | HY-117389 | Homocarbonyltopsentin Homocarbonyltopsentin | 172286-77-0 | 10mM * 1mLin DMSO | 2420元 |
| 2025/12/22 | HY-117389 | Homocarbonyltopsentin | 172286-77-0 | 10 mg | 3500元 |
常见问题列表
生物活性
Homocarbonyltopsentin (PK4C9) 是结合 TSL2 的小分子化合物，高羰基形成蛋白，
与 TSL2 的 pentaloop 构象结合并促进向三叶草构象的转变，增强 SMN2 外显子7 (E7) 剪接，EC50 值为 16 μM。体外研究
Homocarbonyltopsentin (PK4C9) (10-40 μM; 24 hours) shows an up to 5.2-fold decrease in the expression of E7-excluding SMN2 isoforms, and up to three-fold increase in E7-including isoforms in GM03813C cells. Homocarbonyltopsentin (PK4C9) (40 μM; 24 hours) increased 1.5-fold SMN protein expression compared to GM03813C cells treated with DMSO.
RT-PCR
| Cell Line: | GM03813C (SMA) cells; GM03814B fibroblasts cells |
| Concentration: | 10-40 μM |
| Incubation Time: | 24 hours |
| Result: | E7 inclusion reached a maximum of 91% (25% increase, DMSO-treated cells). |
Western Blot Analysis
| Cell Line: | GM03813C (SMA) cells; GM03814B fibroblasts cells |
| Concentration: | 40 μM |
| Incubation Time: | 24 hours |
| Result: | Increased SMN protein in SMA cells. |