1780303-76-5

中文名称 DDR1-IN-1 dihydrochloride

英文名称 DDR1-IN-1 dihydrochloride

CAS 1780303-76-5

分子式 C30H32ClF3N4O3

分子量 589.06

MOL 文件 1780303-76-5.mol

1780303-76-5 结构式

基本信息物理化学性质应用领域常见问题列表 DDR1-IN-1 dihydrochloride价格(试剂级)

基本信息

英文别名

DDR1-IN-1 dihydrochloride

物理化学性质

储存条件-20°C储存

溶解度溶于二甲基亚砜

应用领域

用途一

DDR1-IN-1 is a potent and selective DDR1 inhibitor with IC50 of 105 nM, about 3-fold selectivity over DDR2. DDR1-IN-1 binds to DDR1 in the 'DFG-out' conformation and inhibits DDR1 autophosphorylation in cells at submicromolar concentrations with good selectivity as assessed against a panel of 451 kinases measured. DDR1-IN-1 provides a useful pharmacological probe for DDR1-dependent signal transduction. The DDR1 receptor tyrosine kinase is activated by matrix collagens and has been implicated in numerous cellular functions such as proliferation, differentiation, adhesion, migration, and invasion.

常见问题列表

概述

DDR1-IN-1 dihydrochloride是DDR1受体酪氨酸激酶抑制剂，IC50 值为105 nM，而对 DDR2 的 IC50 为413 nM。

DDR1-IN-1 dihydrochloride价格(试剂级)

报价日期	产品编号	产品名称	CAS号	包装	价格
2026/06/05	HY-13979A	DDR1-IN-1 dihydrochloride DDR1-IN-1 dihydrochloride	1780303-76-5	5 mg	950元
2026/06/05	HY-13979A	DDR1-IN-1 dihydrochloride DDR1-IN-1 dihydrochloride	1780303-76-5	10 mM * 1 mL in Water	1307元
2026/06/05	HY-13979A	DDR1-IN-1 dihydrochloride DDR1-IN-1 dihydrochloride	1780303-76-5	10 mg	1425元