1800487-55-1
1800487-55-1 结构式
物理化学性质
沸点670.3±55.0 °C(Predicted)
密度1.31±0.1 g/cm3(Predicted)
溶解度DMSO: Soluble
Methanol: Soluble
Methanol: Soluble
酸度系数(pKa)14.46±0.46(Predicted)
形态Solid
颜色White to light yellow
应用领域
用途一
OT-82 is a potent NAMPT Inhibitor that targets the strong dependence of hematological malignancies on NAD biosynthesis. OT-82 showed strong efficacy against hematopoietic malignancies including acute myeloblastic and lymphoblastic adult and pediatric leukemias, erythroleukemia, multiple myeloma, and Burkitt's lymphoma in vitro and in mouse xenograft models.常见问题列表
概述
OT-82 是一种强效、选择性和具有口服活性的 NAMPT 的抑制剂。OT-82 对造血源细胞有选择性毒性，以 NAD+ 依赖方式诱导细胞死亡。OT-82 是一种很有前途的抗肿瘤试剂 (antineoplastic agent)，用于血液系统恶性肿瘤的研究。