1821143-79-6
1821143-79-6 结构式
物理化学性质
沸点463.7±37.0 °C(Predicted)
密度1.194±0.06 g/cm3(Predicted)
储存条件-20°C储存
溶解度溶于二甲基亚砜
酸度系数(pKa)2.89±0.10(Predicted)
形态Solid
颜色Light yellow to yellow
1821143-79-6价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2026/06/05 | HY-101284 | 1821143-79-6 DMU2105 | 1821143-79-6 | 5 mg | 880元 |
| 2026/06/05 | HY-101284 | 1821143-79-6 DMU2105 | 1821143-79-6 | 10 mM * 1 mL in DMSO | 968元 |
| 2026/06/05 | HY-101284 | 1821143-79-6 DMU2105 | 1821143-79-6 | 10 mg | 1400元 |
常见问题列表
生物活性
DMU2105 是有效的特异性细胞色素 P4501B1 (CYP1B1) 的抑制剂，其对 CYP1B1 和 CYP1A1 的 IC50 值分别为 10 nM 和 742 nM。靶点
|
CYP1B1 10 nM (IC 50 ) |
CYP1A1 742 nM (IC 50 ) |
体外研究
DMU2105 (Compound 7k) shows 74 and 120-fold selectivity for CYP1B1 over CYP1A1 and CYP1A2. In the presence of DMU2105 however, the EC 50 goes down to 1 μM indicating that the cells have suffered from toxicity which may have been mediated by CYP1B1 inhibition. Un-transfected cells (HEK293: pcDNA3.1), when treated with cisplatin and DMU2105 (10×IC 50 ) do not show any perceptible decrease of cisplatin EC 50 (8.5 μM ± 0.9).