200189-97-5
中文名称
TCH 346 MALEATE; CGP3466B; CGP-3466B; TCH346; TCH-346
英文名称
N-(Dibenz[b,f]oxepin-10-ylmethyl)-N-Methyl-N-(2-propynyl)aminemaleate
CAS
200189-97-5
分子式
C19H17NO.C4H4O4
分子量
391
MOL 文件
200189-97-5.mol
200189-97-5 结构式
基本信息
中文别名
奥米加匹马来酸盐 英文别名
CGP3466BCGP-3466B
TCH 346 maleate
CGP 3466B maleate
CGP 3466 (maleate)
TCH 346 MALEATE
CGP3466B
CGP-3466B
TCH346
TCH-346
N-(Dibenz[b,f]oxepin-10-ylmethyl)-N-Methyl-N-(2-propynyl)aminemaleate
物理化学性质
储存条件Store at +4°C
溶解度溶于二甲基亚砜
形态固体
颜色白色
InChI1S/C19H17NO.C4H4O4/c1-3-12-20(2)14-16-13-15-8-4-6-10-18(15)21-19-11-7-5-9-17(16)19;5-3(6)1-2-4(7)8/h1,4-11,13H,12,14H2,2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
InChIKeySQAZQLMBEHYFJA-BTJKTKAUSA-N
SMILESN(CC1=Cc2c(cccc2)Oc3c1cccc3)(CC#C)C.OC(=O)\C=C/C(=O)O
常见问题列表
生物活性
Omigapil maleate 是一种具有口服活性的 GAPDH 亚硝基化抑制剂，可消除 Aβ1-42 诱导的小鼠 tau 乙酰化，记忆障碍和运动功能障碍，Omigapil maleate 具有研究阿尔茨海默症的潜力。Omigapil maleate (CGP3446B maleate) 是一种有效的凋亡 (apoptosis) 抑制剂。Omigapil maleate 可用于研究先天性肌营养不良 (CMD)。靶点
Apoptosis
体内研究
Treatment of mice with Omigapil (0.1 mg/kg) results in improved muscle regeneration and increased force.
| Animal Model: | 12-week-old dyW/ mag mice |
| Dosage: | 0.1 mg/kg |
| Administration: |
For the first week of drug treatment, administered once daily by intraperitoneal injection.
After weaning (3 weeks of age), applied once daily by oral gavage. |
| Result: |
Reduced the muscle fibre loss.
Many of the functional parameters were significantly improved by omigapil. |