2093088-81-2
中文名称
化合物 T27319
英文名称
2-Propenamide, N-[3-[[3-(3,5-dimethoxyphenyl)-3,4-dihydro-7-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-oxopyrimido[4,5-d]pyrimidin-1(2H)-yl]methyl]phenyl]-
CAS
2093088-81-2
分子式
C35H38N8O4
分子量
634.73
MOL 文件
2093088-81-2.mol
2093088-81-2 结构式
基本信息
中文别名
化合物 T27319 英文别名
2-Propenamide, N-[3-[[3-(3,5-dimethoxyphenyl)-3,4-dihydro-7-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-oxopyrimido[4,5-d]pyrimidin-1(2H)-yl]methyl]phenyl]-物理化学性质
密度1.306±0.06 g/cm3(Predicted)
储存条件2-8°C
溶解度DMSO: 10mg/mL, clear
酸度系数(pKa)13.54±0.70(Predicted)
形态powder
颜色white to beige
应用领域
用途一
FIIN-4 is a first-in-class covalent inhibitor of FGFR (Fibroblast Growth Factor Receptor) that inhibits metastatic breast cancer. Structurally, FIIN-4 is an regional isomer of FIIN-2 (Cat#406652). FIIN-4 effectively blocks 3D metastatic outgrowth as compared with currently available FGFR inhibitors. In vivo application of FIIN-4 potently inhibited the growth of metastatic, patient-derived breast cancer xenografts and murine-derived metastases growing within the pulmonary microenvironment. (Copied from Mol Cancer Ther. 2016 Sep;15(9):2096-106. )