21104-28-9
中文名称
马汉九里香碱
英文名称
Mahanimbine
CAS
21104-28-9
分子式
C23H25NO
分子量
331.45
MOL 文件
21104-28-9.mol
更新日期
2025/06/26 17:18:34
21104-28-9 结构式
基本信息
中文别名
月桔宾马汉九里香碱
(+)-3,11-二氢-3,5-二甲基-3-(4-甲基-3-戊烯-1-基)吡喃并[3,2-A]咔唑
英文别名
MahanimbinMahanimbine
(+)-3,11-Dihydro-3,5-dimethyl-3-(4-methyl-3-penten-1-yl)pyrano[3,2-a]carbazole
Pyrano[3,2-a]carbazole, 3,11-dihydro-3,5-dimethyl-3-(4-methyl-3-penten-1-yl)-, (3S)-
所属类别
天然产物：生物碱物理化学性质
熔点94-95 °C
沸点502.6±39.0 °C(Predicted)
密度1.109
溶解度DMSO: 10 mM
酸度系数(pKa)17.31±0.40(Predicted)
形态neat
稳定性Light Sensitive
马汉九里香碱价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/05/22 | HY-124557 | 马汉九里香碱 Mahanimbine | 21104-28-9 | 1mg | 11750元 |
| 2023/03/20 | HY-124557 | 马汉九里香碱 Mahanimbine | 21104-28-9 | 5mg | 8200元 |
常见问题列表
生物活性
Mahanimbine 是咖喱叶中的一种具有口服活性的生物碱。Mahanimbine 抑制高脂饮食 (HFD) 诱导的小鼠代谢并发症的进展。体内研究
Mahanimbine (2-4 mg/kg; p.o.; daily for 12 weeks) prevents HFD-induced weight gain in mice (male and female).
Mahanimbine prevented HFD-induced hyperlipidemia and fat accumulation in adipose tissue and liver along with the restricted progression of systemic inflammation and oxidative stress.
Mahanimbine treatment improves glucose clearance and upregulates the expression of insulin responsive genes in liver and adipose tissue.
| Animal Model: | Swiss albino mice (7-8 weeks old, both sex) |
| Dosage: | HFD+LD (2 mg/kg of body weight of mahanimbine), HFD+HD (4 mg/kg of body weight of mahanimbine); |
| Administration: | Oral suspension; daily for 12 weeks |
| Result: | Male HFD+LD and HFD+HD groups showed 51.70±6 3.59% and 47.37±3.73% weight gain, respectively, as compared with 71.02±6 6.04% in HFD fed mice whereas female HFD+LD and HFD+HD groups showed 24.31±1.68% and 25.10±2.61% weight gain as compared with HFD group with 36.69±3.60% of weight gain. |