2123484-71-7

中文名称 (±)10(11)-EDP ETHANOLAMIDE

英文名称 10,11-EDP epoxide

CAS 2123484-71-7

分子式 C24H37NO3

分子量 387.56

MOL 文件 2123484-71-7.mol

2123484-71-7 结构式

基本信息物理化学性质应用领域

基本信息

英文别名

10,11-EDP epoxide
(±)10(11)-EDP Ethanolamide

所属类别

生物：生化试剂盒

物理化学性质

储存条件-20°C储存

溶解度DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 50 mg/ml; Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml

应用领域

用途一

(±)10(11)-EDP ethanolamide is an ω-3 endocannabinoid epoxide and cannabinoid (CB) receptor agonist (EC₅₀s = 0.43 and 22.5 nM for CB₁ and CB₂ receptors, respectively). It is produced though direct epoxygenation of docosahexaenoyl ethanolamide (DHEA; ) by cytochrome P450 (CYP) epoxygenases. 10,11-EDP epoxide (12.5 and 25 μM) reduces the viability of 143B metastatic osteosarcoma cells. It induces apoptosis and inhibits cell migration in a wound-healing assay in 143B, MG63, and HOS osteosarcoma cells. (±)10(11)-EDP ethanolamide also reduces tube formation by human umbilical vein endothelial cells (HUVECs) in a Matrigel™ assay.