2149-76-0
中文名称
5-氨基尿苷
英文名称
5-AMINOURIDINE, HYDROCHLORIDE SALT
CAS
2149-76-0
分子式
C9H13N3O6
分子量
259.22
MOL 文件
2149-76-0.mol
2149-76-0 结构式
基本信息
中文别名
5-氨基尿苷 英文别名
5-aminouridineUridine, 5-amino-
5-Aminouridine Hcl
5-AminouridineHClsalt
Uridine, 5-amino-(6CI,7CI,8CI,9CI)
5-amino-1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
5-azanyl-1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
5-amino-1-(3,4-dihydroxy-5-methylol-tetrahydrofuran-2-yl)pyrimidine-2,4-quinone
5-Amino-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
物理化学性质
熔点214-216 °C
密度1.712±0.06 g/cm3(Predicted)
储存条件−20°C
酸度系数(pKa)9.31±0.10(Predicted)
形态Solid
颜色Off-white to light yellow
InChIInChI=1S/C9H13N3O6/c10-3-1-12(9(17)11-7(3)16)8-6(15)5(14)4(2-13)18-8/h1,4-6,8,13-15H,2,10H2,(H,11,16,17)/t4-,5-,6-,8-/m1/s1
InChIKeyYBTWWWIJBCCYNR-UAKXSSHOSA-N
SMILESOC[C@H]1O[C@@H](N2C=C(N)C(=O)NC2=O)[C@H](O)[C@@H]1O
常见问题列表
生物活性
5-Aminouridine 可以修饰核碱基并且可以掺入靶 DNA 中。5-Aminouridine 表现出广泛的生物活性，可抑制肿瘤，真菌和病毒的生长。体外研究
This modified nucleobase, 5-Aminouridine, must exhibit a low enough potential to be oxidized by Os(bpy) 3 3+ . These modified nucleobases can be inserted into the target DNA by direct synthesis using modified phosphoramidites.
体内研究
5-Aminouridine inhibits incorporation of carbamylaspartate into pyrimidines of both RNA and DNA in rat lived and [ 32 P]phosphate into phospholipids and RNA nucleotides of rat liver slices and hepatoma.