2165322-94-9

中文名称化合物AZ1

英文名称 AZ-1

CAS 2165322-94-9

分子式 C17H16BrF4NO2

分子量 422.21

MOL 文件 2165322-94-9.mol

更新日期 2025/07/14 21:25:16

2165322-94-9 结构式

基本信息物理化学性质化合物AZ1价格(试剂级) 常见问题列表

基本信息

中文别名

化合物AZ1
2-[[[5-溴-2-[[4-氟-3-(三氟甲基)苯基]甲氧基]苯基]甲基]氨基]-乙醇

英文别名

USP25/28 inhibitor AZ1
USP25 and 28 inhibitor AZ-1
AZ-1
AZ-1
AZ 1
AZ1
2-((5-bromo-2-((4-fluoro-3-(trifluoromethyl)benzyl)oxy)benzyl)amino)ethanol
Ethanol, 2-[[[5-bromo-2-[[4-fluoro-3-(trifluoromethyl)phenyl]methoxy]phenyl]methyl]amino]-

所属类别

生物化工：抑制剂

物理化学性质

沸点478.5±40.0 °C(Predicted)

密度1.488±0.06 g/cm3(Predicted)

储存条件-20°C储存

溶解度DMSO: ≥ 250 mg/mL (592.12 mM); Water: < 0.1 mg/mL (insoluble)

酸度系数(pKa)14.74±0.10(Predicted)

形态Solid

颜色White to off-white

InChIInChI=1S/C17H16BrF4NO2/c18-13-2-4-16(12(8-13)9-23-5-6-24)25-10-11-1-3-15(19)14(7-11)17(20,21)22/h1-4,7-8,23-24H,5-6,9-10H2

InChIKeyITHSFXDGKQYOED-UHFFFAOYSA-N

SMILESC(O)CNCC1=CC(Br)=CC=C1OCC1=CC=C(F)C(C(F)(F)F)=C1

化合物AZ1价格(试剂级)

报价日期	产品编号	产品名称	CAS号	包装	价格
2025/05/22	HY-117370	化合物AZ1 USP25/28 inhibitor AZ1	2165322-94-9	1 mg	790元
2025/05/22	HY-117370	化合物AZ1 USP25/28 inhibitor AZ1	2165322-94-9	5mg	1270元
2025/05/22	S8904	化合物AZ1 USP25/28 inhibitor AZ1	2165322-94-9	5mg	1270元

常见问题列表

生物活性

AZ1是一种非竞争性的泛素特异性蛋白酶25（USP25）和泛素特异性蛋白酶28（USP28）的双重抑制剂，在Ub-RH110检测中对USP25和USP28的IC50分别0.62 μM和0.7 μM。

靶点

Target	Value
USP25 (Cell-free assay)	0.62 μM
USP28 (Cell-free assay)	0.7 μM

体内研究

USP25/28 inhibitor AZ1 (AZ1; 40 mg/kg; gavage; daily; for 7 days) protects from dextran sulfate sodium (DSS)-induced weight loss and diarrhea and impaired colon shortening.
USP25/28 inhibitor AZ1 (20 mg/kg/day; gavage; 6 times a week in the 1, 3, 6 weeks) treatment significantly reduces tumor numbers in colons. Expression of Wnt-related genes and levels of pSTAT3 are decreased and levels of SOCS3 are increased in tumors. AZ1 gavage does not alleviate DSS-induced colitis in Usp25 ^-/- mice or the spontaneous colitis of Il10 ^-/- mice.
USP25/28 inhibitor AZ1 (20 mg/kg/day; gavage; every 3 days from 13-20 weeks) significantly inhibits tumorigenesis in the colon and prolonged the survival of AOM/Vil-Cre;Trp53 ^fl/fl (VP) mice. AZ1 treatment has minimal effect on tumorigenesis in the USP25-deficient background.

Animal Model:	12-week old male Usp25 ^+/+ and Usp25 ^-/- mice
Dosage:	40 mg/kg
Administration:	Gavage; daily; for 7 days
Result:	Protected from dextran sulfate sodium (DSS)-induced weight loss and diarrhea and impaired colon shortening and potentiated the expression of proinflammatory cytokines and antibacterial peptides in colons of Usp25 ^-/- mice compared to control counterparts.