2188-68-3
中文名称
盐酸石蒜碱
英文名称
Lycorine hydrochloride
CAS
2188-68-3
分子式
C16H17NO4
分子量
287.31
MOL 文件
2188-68-3.mol
更新日期
2025/05/15 09:55:25
2188-68-3 结构式
基本信息
中文别名
水仙碱石蒜碱
石蕊碱
盐酸石蒜碱
盐酸石蒜碱(标准品)
石蒜碱盐酸盐对照品,
盐酸石蒜碱(石蒜碱盐酸盐
异鼠李素-3-Β-D-芸香糖甙
盐酸石蒜碱, 96%(HPLC)
盐酸石蒜碱(石蒜碱盐酸盐,水仙碱)
英文别名
LYCORINLYCORINE
(-)-LYCORINE
NARCISSIN(P)
Lycorine chloride
Hydrochloric Lycorine
Licorin hydrochloride
Lycorine hydrochloride
Licorine hydrochloride
Amarylline hydrochloride
所属类别
原料药：抗阿米巴病及抗滴虫病药物理化学性质
外观性状白色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于石蒜鳞茎。
熔点206 °C
储存条件Keep in dark place,Inert atmosphere,2-8°C
溶解度溶于水(15mg/毫升)
形态粉末
颜色白色至灰白色
稳定性在-20°C下的水溶液可保存长达1个月。
盐酸石蒜碱价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/02/08 | HY-N0289 | 盐酸石蒜碱 Lycorine hydrochloride | 2188-68-3 | 10mg | 321元 |
| 2025/02/08 | HY-N0289 | 盐酸石蒜碱 Lycorine hydrochloride | 2188-68-3 | 10mM * 1mLin DMSO | 353元 |
| 2025/02/08 | HY-N0289 | 盐酸石蒜碱 Lycorine hydrochloride | 2188-68-3 | 25mg | 500元 |
常见问题列表
生物活性
Lycorine hydrochloride 是石蒜的主要活性成分，也是黑色素瘤血管生成抑制剂，具有抗肿瘤活性。Lycorine hydrochloride 能有效抑制 Hey1B 细胞的有丝分裂增殖 (IC50 为 1.2 μM)。靶点
IC50: 1.2 μM (Hey1B cells )
体外研究
Lycorine hydrochloride (0-25 μM; 48 hours; C8161 cells) treatment markedly suppresses the expression of vascular endothelial (VE)-cadherin in a dose-dependent manner and also slightly diminishes the expression of Sema4D in C8161 cells. However, the expression of the other six genes is not affected.
Lycorine hydrochloride (0-25 μM; 48 hours; C8161 cells) treatment markedly reduces VE-cadherin protein levels in C8161 cells in a dose-dependent fashion.
RT-PCR
| Cell Line: | C8161 cells |
| Concentration: | 0 μM, 1.56 μM, 3.13 μM, 6.25 μM, 12.5 μM, 25 μM |
| Incubation Time: | 48 hours |
| Result: | Markedly suppressed the expression of VE-cadherin in a dose-dependent manner and also slightly diminished the expression of Sema4D in C8161 cells. |
Western Blot Analysis
| Cell Line: | C8161 cells |
| Concentration: | 0 μM, 1.56 μM, 3.13 μM, 6.25 μM, 12.5 μM, 25 μM |
| Incubation Time: | 48 hours |
| Result: | Markedly reduced VE-cadherin protein levels in C8161 cells in a dose-dependent fashion. |
体内研究
Lycorine hydrochloride (0-15 μg; subcutaneous injection; for 14 days; BALB/C nude mice) treatment has an inhibitory effect on melanoma cell-mediated tumor vasculogenic mimicry.
| Animal Model: | 6- to 8-week-old BALB/C nude mice |
| Dosage: | 0 μg, 7.5 μg, 15 μg |
| Administration: | Subcutaneous injection; for 14 days |
| Result: | Showed an inhibitory effect on melanoma cell-mediated tumor vasculogenic mimicry. |