219757-90-1
中文名称
219757-90-1
英文名称
SULAMSEROD
CAS
219757-90-1
分子式
C19H28ClN3O5S
分子量
445.96
MOL 文件
219757-90-1.mol
219757-90-1 结构式
基本信息
中文别名
化合物 T13021 英文别名
RS-100302SULAMSEROD
Methanesulfonamide, N-[2-[4-[3-(8-amino-7-chloro-2,3-dihydro-1,4-benzodioxin-5-yl)-3-oxopropyl]-1-piperidinyl]ethyl]-
物理化学性质
沸点647.8±65.0 °C(Predicted)
密度1.319±0.06 g/cm3(Predicted)
储存条件-20°C储存
溶解度溶于二甲基亚砜
酸度系数(pKa)11.22±0.40(Predicted)
常见问题列表
生物活性
Sulamserod 是一种 5-HT4 receptor 拮抗剂，具有抗心律失常的功效。靶点
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5-HT 4 Receptor
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体内研究
Sulamserod (30 mg/kg) prolongs mean ERP (11568 versus 14667 ms, P,0.01) and wavelength (8.360.9 versus 9.960.8 cm, P,0.01), reduces dispersion of ERP (1565 versus 861 ms, P,0.01), and minimally slows conduction velocity (7264 versus 6765 cm/s, P,0.01) in pigs. Sulamserod produces no ventricular electrophysiological effects. Sulamserod terminates atrial flutter in 6 of 8 animals and atrial fibrillation in 8 of 9 animals and prevents reinduction of sustained tachycardia in all animals.