251375-82-3
英文名称
Ethanamine, N,N-dimethyl-2-[(1-methyl-1H-pyrazol-5-yl)phenylmethoxy]-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)
CAS
251375-82-3
分子式
C21H29N3O8
分子量
451.48
MOL 文件
251375-82-3.mol
251375-82-3 结构式
基本信息
英文别名
Cizolirtine citrateEthanamine, N,N-dimethyl-2-[(1-methyl-1H-pyrazol-5-yl)phenylmethoxy]-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)
应用领域
用途一
Cizolirtine, also known as E-4018 (citrate salt) or E-3710, is a calcitonin gene-related peptide antagonist potentially for the treatment of pain, overactive. The efficacy of Cizolirtine has been demonstrated in various models of acute and inflammatory pain in rodents. Cizolirtine may be useful for alleviating some neuropathic somatosensory disorders, in particular cold allodynia, with a reduced risk of undesirable side effects.. Cizolirtine inhibits the spinal release of substance P and CGRP in rats.