31576-51-9
31576-51-9 结构式
基本信息
氨基-甲基二乙二醇
甲氧基-二聚乙二醇-胺
甲基-二聚乙二醇-氨基
2-(2-甲氧基乙氧基)-乙胺
1-(2-氨基乙氧基)-2-甲氧基乙烷
MPEG2-NH2 分枝单甲氧基 聚乙二醇胺
m-PEG2-amine
NH2-PEG2-OME
MeO-EG(2)-NH2
Methyl-PEG2-amine
2-(2-Methoxyethoxy)ethanamine
2-(2-Methoxyethoxy)ethylamine
mPEG2-NH2
EthanaMine, 2-(2-Methoxyethoxy)-
2-(2-Methoxyethoxy)ethoxy]ethenamine
物理化学性质
制备方法
![1H-Isoindole-1,3(2H)-dione, 2-[2-(2-methoxyethoxy)ethyl]-](/CAS/20210305/GIF/179820-15-6.gif)
179820-15-6
31576-51-9
2.2.1.3 2-(2-甲氧基乙氧基)乙胺(2d)的合成 将N-[2-(2-甲氧基乙氧基)乙基]邻苯二甲酰亚胺(2c)(27 mmol)和一水合肼(43 mmol)在乙醇(30 mL)中的混合物于100℃下回流3小时。反应完成后，将混合物冷却至室温，过滤，并蒸发滤液。向残余物中加入丙酮(50 mL)，过滤沉淀。随后，将滤液减压浓缩，得到橙色油状物2d，产率为62%。 1H NMR (500 MHz, CDCl3): δ 1.83 (s, 1H), 2.00 (s, 1H), 2.15 (s, 1H), 2.87 (t, J = 5.3 Hz, 1H), 3.35-3.39 (m, 2H), 3.41 (t, J = 6.4 Hz, 1H), 3.50 (t, J = 5.3 Hz, 1H), 3.52-3.55 (m, 2H), 3.60 (dd, J = 5.7, 3.3 Hz, 1H), 3.64 (dd, J = 5.6, 3.8 Hz, 1H), 3.73 (t, J = 6.5 Hz, 1H) ppm; HR ESI-MS (in MeOH): m/z [M + H]+ calcd. 120.0973, found 120.1047.
参考文献：
[1] Journal of Organic Chemistry, 2011, vol. 76, # 6, p. 1683 - 1691
[2] Journal of Organic Chemistry, 2010, vol. 75, # 3, p. 598 - 610
[3] Inorganica Chimica Acta, 2016, vol. 452, p. 159 - 169
[4] Patent: WO2009/109035, 2009, A1. Location in patent: Page/Page column 57-58
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/05/22 | HY-W008429 | 1-(2-氨基乙氧基)-2-甲氧基乙烷 m-PEG2-Amine | 31576-51-9 | 1 g | 150元 |
| 2025/05/22 | HY-W008429 | 1-(2-氨基乙氧基)-2-甲氧基乙烷 m-PEG2-Amine | 31576-51-9 | 5 g | 301元 |
| 2025/05/22 | HY-W008429 | 1-(2-氨基乙氧基)-2-甲氧基乙烷 m-PEG2-Amine | 31576-51-9 | 10 g | 540元 |
常见问题列表
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PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.