32350-57-5
中文名称
R-Stearoyl Carnitine Chloride
英文名称
R-Stearoyl Carnitine Chloride
CAS
32350-57-5
分子式
C25H48ClNO3
分子量
446.107
MOL 文件
32350-57-5.mol
更新日期
2024/11/26 09:31:12
32350-57-5 结构式
物理化学性质
熔点>158°C (dec.)
储存条件Refrigerator
溶解度DMSO (Slightly, Heated), Methanol (Slightly)
形态Solid
颜色White to Off-White
常见问题列表
生物活性
Stearoyl-L-carnitine chloride 是一种内源性的长链酰基肉碱。Stearoyl-L-carnitine chloride 是一种效力较弱的 GlyT2 抑制剂。Stearoyl-L-carnitine chloride 在浓度高达 3 μM 时可抑制 16.8％ 的甘氨酸响应。靶点
|
GlyT2
|
体外研究
Stearoyl-L-carnitine (0.01-10 μM) inhibits glycine (30 μM) transports by 16.8% at concentrations up 3 μM in
Xenopus laevis
oocytes.
Stearoyl-L-carnitine (500 μM; 30 min) inhibits Na
+
-dependent [
3
H]carnitine (20 nM) uptake by ~50% in HPCT cells.
体内研究
Stearoyl-L-carnitine is significantly decreased in Alzheimer's disease (AD), mild cognitive impairment (MCI) and subjective memory complaint (SMC).