3374-88-7
中文名称
ICA
英文名称
ICA
CAS
3374-88-7
分子式
C13H10N4S
分子量
254.31
MOL 文件
3374-88-7.mol
更新日期
2026/06/29 12:03:03
3374-88-7 结构式
基本信息
英文别名
N-[4-(2-Pyridinyl)-2-thiazolyl]-2-pyridinamine2-Pyridinamine, N-[4-(2-pyridinyl)-2-thiazolyl]-
物理化学性质
沸点466.4±48.0 °C(Predicted)
密度1.339±0.06 g/cm3(Predicted)
储存条件-20°C储存
溶解度DMSO : ≥ 49.5 mg/mL (194.64 mM)
酸度系数(pKa)3.20±0.10(Predicted)
形态Solid
颜色Light brown to brown
ICA价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2026/06/05 | HY-22044 | ICA ICA | 3374-88-7 | 1 mg | 1488元 |
| 2026/06/05 | HY-22044 | ICA ICA | 3374-88-7 | 5 mg | 3600元 |
| 2026/06/05 | HY-22044 | ICA ICA | 3374-88-7 | 10 mM * 1 mL in DMSO | 3960元 |
常见问题列表
生物活性
ICA (N-(pyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine) 是SK通道 (SK channel) 抑制剂。ICA有抗利什曼原虫活性，IC50 值为2.1 µM。靶点
IC50: 2.1 µM (Antileishmanial)
体外研究
The SK channel inhibitor ICA exhibits antiarrhythmic effects. ICA prevents electrically induced runs of atrial fibrillation in the isolated right atrium and induces atrial postrepolarization refractoriness and depolarizes resting membrane potential. ICA at 1 to 10 μM slows conduction velocity. At increased pacing frequencies, SK channel inhibition by ICA (10-30 μM) demonstrates prominent depression of other sodium channel-dependent parameters.