3469-78-1
中文名称
adenosine 5'-monophosphate, monoanhydride with (phosphonomethyl)phosphonic acid
英文名称
adenosine 5'-monophosphate, monoanhydride with (phosphonomethyl)phosphonic acid
CAS
3469-78-1
分子式
C11H18N5O12P3
分子量
505.21
MOL 文件
3469-78-1.mol
3469-78-1 结构式
基本信息
中文别名
化合物 T13547 英文别名
AMP-P(CH2)PAMP PCP,AMPPCP
Einecs 222-435-7
β,γ-MethyleneATP
β,γ-Methylene ATP
Adenylyl methylenediphosphonate
5'-adenylyl (beta,gamma-methylene)diphosphonate
5'-Adenylic acid (phosphonomethyl)phosphonyl ester
5'-Adenylic acid, monohydride with methylenebis(phosphonic acid)
adenosine 5'-monophosphate, monoanhydride with (phosphonomethyl)phosphonic acid
常见问题列表
生物活性
AMP-PCP 是一种 ATP 类似物，可以以 Kd 值 为 3.8 μM 来结合到 Hsp90 的 N 末端结构域。AMP-PCP 结合有利于 Hsp90 活性同型二聚体的形成。靶点
|
HSP90 3.8 μM (Kd) |
体外研究
AMP-PCP binding favors the formation of the active homodimer of Hsp90 by enhancing the slow-motion featured conformational exchanges of those residues (A117-A141) within the lid segment (A111-G135) and around region. In total, 170 non-proline residues are identified for the triple-labeled Hsp90 bound with AMP-PCP.