352336-36-8
中文名称
MLS000544460
英文名称
MLS000544460
CAS
352336-36-8
分子式
C17H12FN3O2S
分子量
341.36
MOL 文件
352336-36-8.mol
352336-36-8 结构式
基本信息
中文别名
化合物 T12080 英文别名
MLS000544460MLS-000544460,MLS000544460
Benzoic acid, 3-fluoro-, 2-[[5-(2-pyridinylthio)-2-furanyl]methylene]hydrazide
物理化学性质
密度1.33±0.1 g/cm3(Predicted)
储存条件2-8°C
溶解度DMSO: 100mg/mL
酸度系数(pKa)11.31±0.46(Predicted)
形态Solid
颜色White to off-white
MLS000544460价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/12/22 | HY-133511 | MLS000544460 | 352336-36-8 | 1 mg | 550元 |
| 2025/12/22 | HY-133511 | MLS000544460 MLS000544460 | 352336-36-8 | 5mg | 1375元 |
| 2025/12/22 | HY-133511 | MLS000544460 | 352336-36-8 | 10 mM * 1 mLin DMSO | 1513元 |
常见问题列表
生物活性
MLS000544460 是一种高度选择性和可逆的 Eya2 磷酸酶抑制剂，Kd 为 2.0 μM，IC50 为 4 μM。MLS000544460 抑制 Eya2 磷酸酶介导的细胞迁移，并具有抗癌活性。靶点
Kd: 2.0 μM (Eya2 phosphatase)
IC50: 4 μM (Eya2 phosphatase)
体外研究
MLS000544460 does not bind Eya3 phosphatase (ED).
MLS000544460 (10 μM) inhibits Eya2-mediated cell migration in human Eya2, Eya2 phosphatase-dead (D274N), and YFP (as a negative control) expressing MCF10A cells.
When Eya2 ED is dialyzed into 10 μM EDTA to remove Mg
2+
, it binds MLS000544460 with a higher affinity (K
d
=0.80 μM), indicating that this class of compounds does not require Mg
2+
for its interaction with the Eya2 ED.