37025-55-1
37025-55-1 结构式
基本信息
卡贝缩官素
卡贝缩宫素
醋酸卡贝缩宫素
卡比托辛/卡贝缩宫素
卡贝缩宫素三氟醋酸盐
醋酸卡贝缩宫素,卡比托辛
卡贝缩宫素-多肽原料委托生产
卡贝缩宫素-多肽制剂一致性评价
醋酸卡贝缩宫素 37025-55-1
Duratocin
Lonactene
Depotocin
Carbansin
CARBETOCIN
Carbetoxin
Carbetocinum
CARBAOXYTOCIN
Carbetocin Acetate
物理化学性质
常见问题列表
Carbetocin is an agonist with about 10-fold lower affinity for the oxytocin receptor but with significantly higher stability and a longer duration of action. Carbetocin has higher affinity to the chimeric E1 receptor and especially to each of the combinations of E1 with the other extracellular domains, i.e. chimeric receptors E13 (K
i
=13 nM), E123 (K
i
=56 nM), and E1234 (K
i
=37 nM).
Carbetocin (2-20 mg/kg; i.p.) has a significant effect of treatment on the percent time spent climbing, swimming and immobile.
Carbetocin (1, 10,100 μg/rat, i.c.v.) reveals a dose-dependent increase in the percent time spent swimming and a corresponding reduction in immobility following acute administration of 100 μg/rat.
| Animal Model: | Male Sprague-Dawley rats weighing between 300 and 500 g |
| Dosage: | 2, 6.4, 20 mg/kg |
| Administration: | IP; single dose |
| Result: | Increased climbing with 6.4 mg/kg and resulted in a significantly greater proportion of time spent swimming with 20 mg/kg. |