4303-67-7
中文名称
1-十二烷基咪唑
英文名称
1-DODECYLIMIDAZOLE
CAS
4303-67-7
分子式
C15H28N2
分子量
236.4
MOL 文件
4303-67-7.mol
更新日期
2025/05/12 10:07:17
4303-67-7 结构式
基本信息
中文别名
1-十二咪唑N-十二烷基咪唑
1-十二烷基咪唑
N-正十二烷基咪唑
1-十二烷基咪唑 25G
(3R,4S)-1-苄基-N,4-二甲基哌啶-3-胺
英文别名
C12IMn-laurylimidazole
1-laurylimidazole
1-dodecliMidazole
N-DODECYLIMIDAZOLE
1-DODECYLIMIDAZOLE
1-dodecyl-imidazol
1-dodecyl-1h-imidazol
1-Dodecylimidazole,97%
1-Dodecylimidazole,95%
所属类别
生物化工：抑制剂物理化学性质
熔点69.5-70.5 °C(Solv: ethyl acetate (141-78-6))
沸点146 °C (0.5 mmHg)
密度0.9624 (rough estimate)
蒸气压0.009Pa at 20℃
折射率1.5312 (estimate)
储存条件Refrigerator
溶解度可溶于氯仿（少许）、甲醇（少许）
酸度系数(pKa)7.08±0.10(Predicted)
形态液体
颜色透明黄色
LogP3.56-5.5 at pH5-9
表面张力45mN/m at 20mg/L and 20℃
EPA化学物质信息1H-Imidazole, 1-dodecyl- (4303-67-7)
1-十二烷基咪唑价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/02/08 | HY-138540 | 1-十二烷基咪唑 1-Dodecylimidazole | 4303-67-7 | 500mg | 100元 |
| 2025/02/08 | XW02430367704 | 1-十二烷基咪唑 | 4303-67-7 | 25G | 1543元 |
| 2025/02/08 | HY-138540 | 1-十二烷基咪唑 1-Dodecylimidazole | 4303-67-7 | 1 g | 160元 |
常见问题列表
生物活性
1-Dodecylimidazole (N-Dodecylimidazole) 是一种溶酶体活性洗涤剂和细胞毒性剂。1-Dodecylimidazole 通过其在溶酶体中的酸依赖性积累、溶酶体膜的破坏和半胱氨酸蛋白酶释放到细胞质中而导致细胞死亡。1-Dodecylimidazole 具有降胆固醇和广谱抗真菌活性。体外研究
N-dodecylimidazole, an acid activated detergent with a pKa of 6.3, has been shown to be cytotoxic to cells in culture. N-dodecylimidazole displayed extracellular pH (pHe)-dependent cytotoxicity against EMT-6 and MGH U1 cells. cell killing was dose dependent and was 100-fold greater at pHe 6.0 than pHe 7.0.
体内研究
The hypocholesterolaemic activity of 1-dodecylimidazole results in part from the inhibition of cholesterol biosynthesis at the level of 2,3-oxidosqualene sterol cyclase.
1-dodecylimidazole (150 mg/kg body wt; by stomach tube; daily for 10 days) has lower serum cholesterol concentrations than control rats.
| Animal Model: | Male rats |
| Dosage: | 150 mg/kg body wt |
| Administration: | By stomach tube; daily for 10 days |
| Result: | Had significantly lower serum cholesterol concentrations than untreated animals. |