4542-23-8
中文名称
(2S)-2-[[9-[(2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-6-yl]amino]butanedioic acid
英文名称
(2S)-2-[[9-[(2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-6-yl]amino]butanedioic acid
CAS
4542-23-8
分子式
C14H17N5O8
分子量
383.31
MOL 文件
4542-23-8.mol
4542-23-8 结构式
基本信息
中文别名
N6琥珀酰腺苷 英文别名
SuccinoadenosineSuccinyladenosine
N6-Succinyl Adenosine
(S)-N-(1,2-Dicarboxyethyl)adenosine
N-<9-(β-ribofuranosyl)-9H-purin-6-yl>-L-aspartic acid
N-(9-β-D-Ribofuranosyl-9H-purin-6-yl)-L-aspartic Acid
6-(1,2-DicarboxyethylaMino) -9-β-D-ribofuranosylpurine
L-Aspartic acid, N-(9-β-D-ribofuranosyl-9H-purin-6-yl)-
(2S)-2-[[9-[(2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-6-yl]amino]butanedioic acid
(S)-2-((9-((2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)amino)succinic acid
物理化学性质
熔点>180°C (dec.)
沸点816.4±75.0 °C(Predicted)
密度2.02±0.1 g/cm3(Predicted)
储存条件-20°C Freezer
溶解度DMSO (Slightly), Methanol (Slightly, Heated)
酸度系数(pKa)3.52±0.23(Predicted)
形态Solid
颜色White to Off-White
应用领域
用途1
Succinyladenosine (S-Ado) is a biochemical marker of adenylosuccinase deficiency - the genetic defect of purine de novo synthesis. 聽S-Ado has been previously reported as normally undetectable in cereb
rospinal fluid (CSF) of children not suffering from this defect.常见问题列表
生物活性
Succinyladenosine，是胞内腺苷酸 (S-AMP) 经 5-核苷酸酶脱磷酸化的产物，是腺苷酸琥珀酸酶 (ASL) 缺乏的生化标志。靶点
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Human Endogenous Metabolite
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体外研究
The presence of high concentrations of Succinyladenosine (S-Ado) in the human cerebrospinal fluid (CSF) in the range of 100–500 μmol/L is a diagnostic marker for inherited enzyme deficiency of ASL.