456-12-2
中文名称
印枳碱
英文名称
Aegelin
CAS
456-12-2
分子式
C18H19NO3
分子量
297.348
MOL 文件
456-12-2.mol
更新日期
2026/01/14 15:37:00
456-12-2 结构式
基本信息
中文别名
印枳碱N-[2-羟基-2-(4-甲氧基苯基)乙基]肉桂酰胺
英文别名
AegelinAegeline
N-CinnaMoyl-β-hydroxy-4-Methoxyphenyl-aethylaMin
N-Cinnamoyl-β-hydroxy-4-methoxyphenyl-aethylamin
N-(2-Hydroxy-2-(4-Methoxyphenyl)ethyl)cinnaMaMide
(E)-N-[2-Hydroxy-2-(4-methoxyphenyl)ethyl]cinnamamide
(E)-N-[2-hydroxy-2-(4-methoxyphenyl)ethyl]-3-phenylprop-2-enamide
Aegeline,N-[2-hydroxy-2(4-Methoxyphenyl) ethyl]-3-phenyl-2-propenaMide
2-Propenamide, N-[2-hydroxy-2-(4-methoxyphenyl)ethyl]-3-phenyl-, (2E)-
AegelineQ: What is Aegeline Q: What is the CAS Number of Aegeline Q: What is the storage condition of Aegeline Q: What are the applications of Aegeline
所属类别
医药中间体：原料药中间体物理化学性质
熔点178-179℃
沸点567.7±50.0 °C(Predicted)
密度1.178±0.06 g/cm3(Predicted)
储存条件under inert gas (nitrogen or Argon) at 2-8°C
酸度系数(pKa)13.70±0.20(Predicted)
形态粉末晶体
颜色白色至浅黄色
主要应用pharmaceutical (small molecule)
InChI1S/C18H19NO3/c1-22-16-10-8-15(9-11-16)17(20)13-19-18(21)12-7-14-5-3-2-4-6-14/h2-12,17,20H,13H2,1H3,(H,19,21)/b12-7+
InChIKeyQRFDENJATPJOKG-KPKJPENVSA-N
SMILESN(CC(O)c2ccc(cc2)OC)C(=O)\C=C\c1ccccc1
常见问题列表
用途
印枳碱是一种化合物，可以从生长在印度的Aegle marmelos树的叶子中提取。研究发现这种树的精油对21种细菌有效。印枳碱也有抗肥胖作用。
用途
印枳碱为芳香类衍生物，其可用作医药合成中间体。生物活性
Aegeline 是一种主要生物碱，模拟酵母 SNARE 蛋白 Sec22p 抑制酵母 α-突触核蛋白和 Bax 毒性。Aegeline 恢复 αsyn 或 Bax 抑制的酵母细胞生长。体外研究
Aegeline also prevents growth block in cells expressing the more toxic A53T α-synuclein mutant. Restoration of cell growth occurred through inhibition of increased ROS levels, mitochondrial membrane potential loss and nuclear DNA fragmentation, characteristics of apoptosis manifested in α-synuclein or
Bax-expressing cells.
Aegeline shows weak inhibitory effects on the histamine release from RPMCs, even though still succeed to inhibit when the histamine release induced by thapsigargin.