485-19-8

中文名称牛心果鹼

英文名称 (S)-1,2,3,4-tetrahydro-1-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2-methylisoquinolin-7-ol

CAS 485-19-8

分子式 C19H23NO4

分子量 329.39

MOL 文件 485-19-8.mol

更新日期 2023/03/20 15:41:19

485-19-8 结构式

基本信息物理化学性质安全数据应用领域牛心果鹼价格(试剂级) 常见问题列表

基本信息

中文别名

瑞枯灵
牛心果
牛心果鹼
网状番荔枝碱
瑞枯灵(牛心果碱)
瑞枯灵(牛心果碱 )查备注

英文别名

reticuline
(S)-Reticuline
Reticuline (>90% ee)
(1S)-1-[(3-hydroxy-4-methoxy-phenyl)methyl]-6-methoxy-2-methyl-3,4-dihydro-1H-isoquinolin-7-ol
(S)-1,2,3,4-tetrahydro-1-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2-methylisoquinolin-7-ol
2-Methoxy-5-[[(1S)-2-methyl-6-methoxy-7-hydroxy-1,2,3,4-tetrahydroisoquinoline]-1-ylmethyl]phenol
7-Isoquinolinol, 1,2,3,4-tetrahydro-1-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2-methyl-, (1S)-
[1S,(+)]-1,2,3,4-Tetrahydro-1-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2-methylisoquinolin-7-ol
[1S,(+)]-1,2,3,4-Tetrahydro-1-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2-methylisoquinoline-7-ol

所属类别

天然产物：生物碱

物理化学性质

外观性状白色粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于印防己，山胡椒，凹叶厚朴。

熔点125-126°C

沸点648.96°C (rough estimate)

密度1.4371 (rough estimate)

折射率1.6800 (estimate)

储存条件Sealed in dry,2-8°C

溶解度溶于二甲基亚砜

酸度系数(pKa)9.95±0.10(Predicted)

形态Solid

颜色Off-white to yellow

旋光度 (Optical Rotation)+88.318 (c 0.21, ethanol)

InChIInChI=1S/C19H23NO4/c1-20-7-6-13-10-19(24-3)17(22)11-14(13)15(20)8-12-4-5-18(23-2)16(21)9-12/h4-5,9-11,15,21-22H,6-8H2,1-3H3/t15-/m0/s1

InChIKeyBHLYRWXGMIUIHG-HNNXBMFYSA-N

SMILES[C@H]1(CC2=CC=C(OC)C(O)=C2)C2=C(C=C(OC)C(O)=C2)CCN1C

安全数据

危险性符号(GHS) GHS hazard pictograms

GHS06

警示词危险

危险性描述H301+H311+H331-H315-H319

防范说明P501-P261-P270-P271-P264-P280-P337+P313-P305+P351+P338-P361+P364-P332+P313-P301+P310+P330-P302+P352+P312-P304+P340+P311-P403+P233-P405

应用领域

用途1

瑞枯灵具有抗血小板聚集，抑制子宫平滑肌收缩的作用。

牛心果鹼价格(试剂级)

报价日期	产品编号	产品名称	CAS号	包装	价格
2025/05/22	HY-N1356	牛心果鹼 Reticuline	485-19-8	1mg	2000元
2025/05/22	HY-N1356	牛心果鹼 Reticuline	485-19-8	5mg	4600元

常见问题列表

生物活性

Reticuline 分离自 Litsea cubeba，通过 JAK2/STAT3 和 NF-κB 信号通路显示抗炎作用。Reticuline 还可抑制 TNF-α 和 IL-6 的 mRNA 表达，并降低 JAK2 和 STAT3 的磷酸化水平。Reticuline 具有心血管作用。

靶点

JAK2

STAT3

NF-κB

体外研究

Reticuline (3 μM, 30 μM, 300 μM, 900 μM and 1.5 mM) inhibits in a concentration-dependent manner the contractions induced by Phenylephrine (1 μM), KCl (80 mM) and KCl (30 mM), (IC ₅₀ =40±10, 240±40 and 300±40 μM, respectively) in isolated rat aortic rings with intact endothelium.
Reticuline (3 μM, 30 μM, 300 μM, 900 μM and 1.5 mM) antagonizes CaCl ₂ -induced contractions, and also inhibits the intracellular calcium dependent transient contractions induced by Norepinephrine (1μM), but not those induced by Caffeine (20 mM).

体内研究

Reticuline (5, 10 and 20 mg/kg, i. v., randomly) injections produced an intense hypotension in normotensive rats. The hypotensive effect of Reticuline is probably due to a peripheral vasodilation in consequence of: 1) muscarinic stimulation and NOS activation in the vascular endothelium, 2) voltage-dependent Ca ²⁺ channel blockade and/or 3) inhibition of Ca ²⁺ release from norepinephrine-sensitive intracellular stores.