52238-35-4
52238-35-4 结构式
基本信息
中文别名
化合物 T102009-羟基玫瑰树碱盐酸盐
9-HYDROXYELLIPTICINE 盐酸
英文别名
Nsc2641369-hydroxyellipticine HCl salt
9-Hydroxyellipticine, Hydrochloride
物理化学性质
熔点>223oC (dec.)
储存条件Hygroscopic, -20°C Freezer, Under inert atmosphere
溶解度DMSO (Slightly, Heated), Methanol (Slightly, Sonicated)
形态Solid
颜色Orange to Dark Orange
Nsc264136价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/05/22 | HY-101775A | 9-Hydroxyellipticine hydrochloride | 52238-35-4 | 1 mg | 670元 |
常见问题列表
生物活性
9-Hydroxyellipticine hydrochloride 是 Topo II 和RyR 的抑制剂。9-Hydroxyellipticine hydrochloride 具有抗肿瘤、抗氧化和释放儿茶酚胺的活性。 9-Hydroxyellipticine hydrochloride 对 Hela S-3 和293T 细胞的IC50 值分别为1.6 μM 和1.2μM。靶点
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Topoisomerase II
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体外研究
9-Hydroxyellipticine (9HE) causes selective inhibition of p53 protein phospborylation in Lewis lung carcinoma and SW480 (human colon cancer cell line) in a concentration-dependent manner from 0.1 to 100 μM.
体内研究
9-Hydroxyellipticine (5 or 10 mg/kg, ip) results in chromosome clumping and sister chromatid exchange in murine bone marrow cells.
| Animal Model: | Three- to five-month-old C57B1/6 male mice. |
| Dosage: | 5 or 10 mg/kg. |
| Administration: | IP. |
| Result: | Resulted in chromosome clumping, chromatid aberrations, and micronuclei formation in murine bone marrow cells. |