537034-15-4
中文名称
PAOA
英文名称
N-(2-Aminophenyl)-N'-phenylheptanediamide
CAS
537034-15-4
分子式
C19H23N3O2
分子量
325.4
MOL 文件
537034-15-4.mol
更新日期
2026/01/15 08:53:05
537034-15-4 结构式
基本信息
中文别名
化合物PAOAHDAC抑制剂(NKL 22)
英文别名
NKL 22HDACi-4b
MDK-4154
NKL22, >98%
NKL 22, >98%
HDAC inhibitor IV
Histone Deacetylase Inhibitor IV
N-(2-Aminophenyl)-N'-phenylheptanediamide
N1-(2-AMinophenyl)-N7-phenylheptanediaMide
Heptanediamide, N1-(2-aminophenyl)-N7-phenyl-
所属类别
生物化工：激动剂抑制剂物理化学性质
熔点159-161°C
沸点627.9±40.0 °C(Predicted)
密度1.212±0.06 g/cm3(Predicted)
储存条件-20°C冷冻
溶解度可溶于二甲基亚砜、甲醇
酸度系数(pKa)14?+-.0.70(Predicted)
形态米色固体
颜色灰白色至浅米色
InChI1S/C19H23N3O2/c20-16-11-7-8-12-17(16)22-19(24)14-6-2-5-13-18(23)21-15-9-3-1-4-10-15/h1,3-4,7-12H,2,5-6,13-14,20H2,(H,21,23)(H,22,24)
InChIKeyZAIULUYKQLVQFH-UHFFFAOYSA-N
应用领域
用途1
Histone deacetylase inhibitor IV. A cell-permeable pimeloylanilide compound that acts as a FXN-(frataxin gene) specific HDAC inhibitor. Reverses the silencing of FXN transcription in FRDA (Friedrich鈥檚
ataxia) cells due to hypoacetylation of histones H3 and H4.