56092-81-0
56092-81-0 结构式
基本信息
离子霉素(乙醇溶液)
IONOMYCIN游离态
离子霉素, 来源于链霉菌
来自共生链霉菌的IONOMYCIN
罗红霉素(游离酸)(链霉菌属载体)
SQ-23377
IONOMYCIN
SQ 23377, EM 94
Ionomycinefreeacid
IONOMYCIN (SQ23377)
IONOMYCIN USP/EP/BP
Ionomycin Free Acid (85%)
IONOMYCIN, STREPTOMYCES CONGLOBATUS
Ionomycin from Streptomyces conglobatus
物理化学性质
安全数据
常见问题列表
Calcium ionophore
Ionomycin is a Calcium ionophore and an antibiotic produced by
Streptomyces conglobatus
.
Addition of 2 μM Ionomycin to LCLC 103H cells causes an instantaneous increase in intracellular Ca
2+
concentration from 50 to 180 nM. DNA and protein analysis in Ionomycin-treated cultures revealed DNA fragmentation and PARP cleavage to an 85-kDa fragment typical of caspase-mediated apoptosis. Necrosis could be detected in ~1-5% of the Ionomycin treated cells. Caspase activation in whole cells was followed by monitoring the increase in activity against Ac-DEVD-amc following Ionomycin treatment.
Ionomycin-mediated cleavage and exosome release. Following Ionomycin exposure, medium conditioned by SKOV3ip cells had increased amounts of exosomes containing the L1-32 cleavage fragment.