686772-17-8

中文名称 CS-2394

英文名称 IWP 4

CAS 686772-17-8

分子式 C23H20N4O3S3

分子量 496.62

MOL 文件 686772-17-8.mol

更新日期 2025/05/12 11:39:02

686772-17-8 结构式

基本信息物理化学性质安全数据图谱信息 CS-2394价格(试剂级) 常见问题列表

基本信息

中文别名

化合物IWP 4
2-((3-(2-甲氧基苯基)-4-氧代-3,4,6,7-四氢噻吩并[3,2-D]嘧啶-2-基)硫代)-N-(6-甲基苯并[D]噻唑-2-基)乙酰胺

英文别名

IWP 4
CS-2394
IWP4
IWP 4
IWP-4 >=95% (HPLC)
Wnt Inhibitor IWP-4
Inhibitor of Wnt Production-4
N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-3-(2-methoxyphenyl)-4-oxothieno[3,2-d]pyrimidin-2-yl)thio]-acetamide
Acetamide, N-(6-methyl-2-benzothiazolyl)-2-[[3,4,6,7-tetrahydro-3-(2-methoxyphenyl)-4-oxothieno[3,2-d]pyrimidin-2-yl]thio]-
2-((3-(2-methoxyphenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide

所属类别

生物化工：激动剂抑制剂

物理化学性质

密度1.51±0.1 g/cm3(Predicted)

储存条件-20°C

溶解度insoluble in H2O; insoluble in EtOH; insoluble in DMSO

酸度系数(pKa)9.01±0.70(Predicted)

形态粉末

颜色白色至浅棕色

安全数据

危险性符号(GHS) GHS hazard pictograms

GHS07

警示词警告

危险性描述H302

防范说明P280-P305+P351+P338

WGK Germany3

图谱信息

CS-2394(686772-17-8)核磁图(¹HNMR)

CS-2394价格(试剂级)

报价日期	产品编号	产品名称	CAS号	包装	价格
2025/02/08	HY-12879	IWP-4	686772-17-8	1 mg	438元
2025/02/08	HY-12879	CS-2394 IWP-4	686772-17-8	5mg	1500元
2025/02/08	HY-12879	CS-2394 IWP-4	686772-17-8	10mg	2500元

常见问题列表

生物活性

IWP-4 是一种小分子 Wnt 抑制剂，其 IC50 值为 25 nM。

靶点

IC50: 25 nM (Wnt)

体外研究

IWP-4 is a small molecule Wnt inhibitor with an IC ₅₀ of 25 nM. IWP-4 induces the expression of cardiac markers, including cardiac troponin I (CTNI) and cardiac myosin heavy chain bright cells (MYH ^{hi +} ). IWP-4 also results in the appearance of beating foci (0.44±0.10 SEM beats per second), which is absent in all cultures not receiving IWP-4. Further, flow cytometric analysis shows that there are significantly more MYH ^{lo +} cells in IWP-4 treated cultures (P<0.0002) compare with untreated cultures at day 16, being 17.0±1.3 SD% and 5.4±1.4 SD%, respectively. Quantification of NKX2-5 protein expression shows that 63% (481/817) of IWP-4 treated cells display nuclear NKX2-5 expression. Mesenchymal precursor cells (MPCs) treated with IWP-4 show no significant changes in the expression of AXIN2 , CTNNB1 and GSK3B as compare to osteogenic medium alone on day 7, but MPCs treated with IWP-4 express elevates levels of DKK1 and GSK3β on day 21. IWP-4 also causes a significant down regulation of SPARC and COL1A1 .