693790-96-4

中文名称 D-Phenylalanine, N-[6-[4-(phenylmethoxy)phenyl]-4-pyrimidinyl]-

英文名称 D-Phenylalanine, N-[6-[4-(phenylmethoxy)phenyl]-4-pyrimidinyl]-

CAS 693790-96-4

分子式 C26H23N3O3

分子量 425.48

MOL 文件 693790-96-4.mol

693790-96-4 结构式

基本信息物理化学性质图谱信息 D-Phenylalanine, N-[6-[4-(phenylmethoxy)phenyl]-4-pyrimidinyl]-价格(试剂级) 常见问题列表

基本信息

中文别名

化合物 T26745
化合物BAY 73-1449

英文别名

BAY 73-1449
D-Phenylalanine, N-[6-[4-(phenylmethoxy)phenyl]-4-pyrimidinyl]-
vessel,portal,pressure,mesenteric,porto-systemic,inhibit,BAY 731449,blood,BAY 73 1449,prostacyclin,inflow,BAY 73-1449,splenic,Inhibitor,shunt,lower,Prostaglandin Receptor,outflow

物理化学性质

沸点700.4±60.0 °C(Predicted)

密度1.273±0.06 g/cm3(Predicted)

储存条件-20°C储存

溶解度DMSO: 250 mg/mL (587.57 mM)

酸度系数(pKa)3.35±0.10(Predicted)

形态Solid

颜色White to off-white

图谱信息

D-Phenylalanine, N-[6-[4-(phenylmethoxy)phenyl]-4-pyrimidinyl]-(693790-96-4)核磁图(¹HNMR)

D-Phenylalanine, N-[6-[4-(phenylmethoxy)phenyl]-4-pyrimidinyl]-价格(试剂级)

报价日期	产品编号	产品名称	CAS号	包装	价格
2025/02/08	HY-118941	BAY 73-1449	693790-96-4	1 mg	700元
2025/02/08	HY-118941	D-Phenylalanine, N-[6-[4-(phenylmethoxy)phenyl]-4-pyrimidinyl]- BAY 73-1449	693790-96-4	10mM * 1mLin DMSO	1381元
2025/02/08	HY-118941	D-Phenylalanine, N-[6-[4-(phenylmethoxy)phenyl]-4-pyrimidinyl]- BAY 73-1449	693790-96-4	5mg	1475元

常见问题列表

生物活性

BAY 73-1449 是一种选择性前列环素受体 (prostacyclin receptor, IP) 的拮抗剂，在人 HEL 细胞和大鼠 DRG 的 cAMP 分析中具有很高的效价 (IC50 值小于 0.1 nM)。BAY 73-1449 可用于降血压的研究。

靶点

IP Receptor

<0.1 nM (IC ₅₀ )

体内研究

BAY 73-1449 (0.1-1 mg/kg; i.v.) does not significantly reduce mesenteric inflow, but significantly reduces splenic shunt vessel outflow in rats.
BAY 73-1449 (1-5 mg/kg, s.c. once daily for 7 d) has no effects on the degree of porto-systemic shunting in rats.
BAY 73-1449 (1 mg/kg, s.c. once daily for 7 d), has no effects on portal pressures in rats.

Animal Model:	Male Wistar rats (250-350 g) are ligated portal vein
Dosage:	0.1, 1 mg/kg
Administration:	A single i.v.
Result:	Significantly reduced shunt flow without affecting mesenteric flow.