792957-74-5
792957-74-5 结构式
基本信息
ER-000444793 (ER000444793)
4-Quinolinecarboxamide, 1,2-dihydro-2-oxo-N-[2-(phenylmethyl)phenyl]-
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/05/22 | HY-100852 | 792957-74-5 ER-000444793 | 792957-74-5 | 1mg | 880元 |
| 2025/05/22 | HY-100852 | ER-000444793 | 792957-74-5 | 10 mM * 1 mLin DMSO | 1559元 |
| 2025/05/22 | HY-100852 | 792957-74-5 ER-000444793 | 792957-74-5 | 5mg | 2000元 |
常见问题列表
IC50: 2.8 μM (mPTP)
ER-000444793 is a small molecule, non-toxic mPTP inhibitor with a mechanism of action independent of CypD inhibition. ER-000444793 potently and dose-dependently inhibits Ca 2+ -induced mPT. ER-000444793 binds CypD, a CsA/CypD homogenous time-resolved fluorescence (HTRF) assay is used to study compound binding. Both CsA and SfA dose-dependently decrease HTRF signal, suggesting displacement of labelled CsA from rhCypD protein (CsA IC 50 =23 nM and SfA IC 50 = 5 nM). In contrast, ER-000444793 has no effect up to a concentration of 50 μM, indicating lack of displacement of labelled-CsA from rhCypD protein. Together, these data suggest the mechanism of ER-000444793 in delaying mPT is independent of CypD functional inhibition.