821794-90-5
中文名称
1-[4-氨基-7-(3-羟基丙基)-5-(4-甲基苯基)-7H-吡咯并[2,3-D]嘧啶-6-基]-2-氯乙酮
英文名称
1-[4-AMino-7-(3-hydroxypropyl)-5-(4-Methylphenyl)-7H-pyrrolo[2,3-d]pyriMidin-6-yl]-2-chloro-ethanone
CAS
821794-90-5
分子式
C18H19ClN4O2
分子量
358.82
MOL 文件
821794-90-5.mol
更新日期
2024/11/15 18:20:30
821794-90-5 结构式
基本信息
中文别名
1-[4-氨基-7-(3-羟基丙基)-5-(4-甲基苯基)-7H-吡咯并[2,3-D]嘧啶-6-基]-2-氯乙酮1-[4-AMINO-7-(3-HYDROXYPROPYL)-5-(4-METHYLPHENYL)-7H-PYRROLO[2,3-D]PYRIMIDIN-6-YL]-2-CHLORO-ETHANONE (>
90%)
英文别名
1-[4-AMino-7-(3-hydroxypropyl)-5-(4-Methylphenyl)-7H-pyrrolo[21-(4-Amino-7-(3-hydroxypropyl)-5-(p-tolyl)-7h-pyrrolo[2,3-d]pyrimidin-6-yl)-2-chloroethanone
1-[4-amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)pyrrolo[2,3-d]pyrimidin-6-yl]-2-chloroethanone
1-[4-AMino-7-(3-hydroxypropyl)-5-(4-Methylphenyl)-7H-pyrrolo[2,3-d]pyriMidin-6-yl]-2-chloro-ethanone
Ethanone, 1-[4-amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-chloro-
1-[4-Amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-chloro-ethanone (>
1-[4-AMino-7-(3-hydroxypropyl)-5-(4-Methylphenyl)-7H-pyrrolo[2,3-d]pyriMidin-6-yl]-2-chloro-ethanone (>90%)
物理化学性质
熔点170-172°C
沸点647.5±55.0 °C(Predicted)
密度1.39±0.1 g/cm3(Predicted)
储存条件-20°C Freezer
溶解度Chloroform, methanol
酸度系数(pKa)14.43±0.10(Predicted)
形态Solid
颜色Off-White to Pale Yellow
常见问题列表
生物活性
CMK是 RSK2激酶抑制剂，与FMK相比，具有相似的效力但化学稳定性较低。体外研究
CMK inhibits the growth of Cdc5 (L158G) with IC 50 of 36 nM, greater than 30 μM for wild type Cdc5. CMK exhibits a concentration-dependent first cell cycle mitotic arrest in the cdc5-as1 strain with an IC 50 of 1.1 μM. CMK inhibition of Cdc5 (L158G) leads to a first cell cycle anaphase arrest and delay in anaphase spindle migration.