85278-24-6
中文名称
(E)-BETA-(氯甲基亚基)苯乙胺盐酸盐
英文名称
MDL 72274A
CAS
85278-24-6
分子式
C9H11Cl2N
分子量
204.09
MOL 文件
85278-24-6.mol
85278-24-6 结构式
基本信息
中文别名
化合物 T33265(E)-BETA-(氯甲基亚基)苯乙胺盐酸盐
英文别名
MDL 72274AMDL72274 HCl
Beta-(Chloromethylene)benzeneethanamine hydrochloride
(E)-beta-(Chloromethylene)benzeneethanamine hydrochloride
MDL72274
MDL-72274
MDL 72274
MDL72274A
MDL-72274A
MDL 72274A
MDL72274 HCL
应用领域
用途一
MDL-72274 HCl is selective and potent inhibitors of SSAO for treatment of Parkinson diseases. MDL-72974 is a potent (IC50 = 10(-9) M) inhibitor of both MAO-B and SSAO, with 190-fold lower affinity for MAO-A. In clinical studies, oral doses as low as 100 micrograms produced substantial inhibition of platelet MAO-B. One or 4 mg MDL-72274 HCl given daily for 28 days to 40 Parkinson's patients treated with L-dopa produced statistically significant reductions in the Unified Parkinson's Disease Rating Scale. MAO-B inhibitors, such as MDL 72974A and L-deprenyl, offer the potential of being neuroprotective in Parkinson's Disease and other neurogenerative disorders.