85375-85-5

中文名称化合物 SKF89976A HCL

英文名称 SK&F 89976-A

CAS 85375-85-5

分子式 C22H25NO2

分子量 335.44

MOL 文件 85375-85-5.mol

85375-85-5 结构式

基本信息物理化学性质应用领域

基本信息

中文别名

化合物 SKF89976A HCL

英文别名

SKF-89976
1-(4,4-Diphenyl-3-butenyl)-3-piperidinecarboxylic acid

物理化学性质

沸点531.4±50.0 °C(Predicted)

密度1.121±0.06 g/cm3(Predicted)

酸度系数(pKa)3.87±0.20(Predicted)

应用领域

用途一

SKF89976A is a potent GABA uptake inhibitor, which is selective for GAT-1 (IC50 values are 0.13, 550, 944 and 7210 μM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively). SKF89976A inhibits transport current competitively (Ki = 7 μM) and transmitter-gated current non-competitively (Ki = 0.03 nM). It is able to pass the blood-brain barrier after systemic administration and is active in vivo.