863971-44-2
中文名称
FMOC-3AA-OH
英文名称
(5S,9S,11S,12R)-11-((S)-sec-butyl)-1-(9H-fluoren-9-yl)-5,9-diisopropyl-12-Methoxy-4,10-diMethyl-3,6,8-trioxo-2-oxa-4,7,10-triazatetradecan-14-oic acid
CAS
863971-44-2
分子式
C36H51N3O7
分子量
637.81
MOL 文件
863971-44-2.mol
更新日期
2025/05/27 23:37:21

基本信息
中文别名
一甲基奥瑞他汀中间体10化合物FMOC-3VVD-OH
(5S,9S,11S,12R)-11 - ((S) - 仲丁基)-1-(9H-芴-9-基)-5,9-
4-[(2-{2-[(9H-氟-9-基甲氧基羰基)-甲基氨基]-3-甲基-丁酰基氨基}-3-甲基-丁酰基)-甲基氨基]-3-甲氧基-5-甲基庚酸
(5S,8S,11S,12R)-11-((S)-仲丁基)-1-(9H-芴-9-基)-5,9-二异丙基-12-甲氧基-4,10-二甲基 3,6,8-三氧代-2-氧杂-4,7,10-三氮杂十四烷-14-酸
英文别名
FMOC-3AA-OHFmoc-3AA-orl
Fmoc-3vvd-OH
Tripeptide (MMAE-3)
Fmoc-Meval-val-dolaisoleucine-OH
N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-valyl-N-[(1S,2S)-1-[(1R)-2-carboxy-1-methoxyethyl]-2-methylbutyl]-N-methyl-L- valinamide
L-Valinamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-valyl-N-[(1S,2S)-1-[(1R)-2-carboxy-1-methoxyethyl]-2-methylbutyl]-N-methyl-
(5S,8S,12R)-11-((S)-sec-butyl)-1-(9H-fluoren-9-yl)-5,8-diisopropyl-12-methoxy-4,10-dimethyl-3,6,9-trioxo-2-oxa-4,7,10-triazatetradecan-14-oic acid
(5S,8S,11S,12R)-11-((S)-sec-butyl)-1-(9H-fluoren-9-yl)-5,8-diisopropyl-12-methoxy-4,10-dimethyl-3,6,9-trioxo-2-oxa-4,7,10-triazatetradecan-14-oic acid
(5S,9S,11S,12R)-11-((S)-sec-butyl)-1-(9H-fluoren-9-yl)-5,9-diisopropyl-12-Methoxy-4,10-diMethyl-3,6,8-trioxo-2-oxa-4,7,10-triazatetradecan-14-oic acid
所属类别
生物:蛋白与多肽物理化学性质
沸点793.0±60.0 °C(Predicted)
密度1.144±0.06 g/cm3(Predicted)
溶解度DMSO: ≥ 37 mg/mL (58.01 mM)
酸度系数(pKa)4.08±0.10(Predicted)
形态Solid
颜色White to off-white
水溶解性Water: < 0.1 mg/mL (insoluble)
InChIKeyJDMOCVJBADMSJP-FCUBIXSHSA-N
SMILESC(NC(=O)[C@H](C(C)C)N(C(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O)C)(=O)[C@H](C(C)C)N([C@H]([C@H](OC)CC(O)=O)[C@@H](C)CC)C
常见问题列表
用途
Fmoc-3VVD-OH是可裂解的ADC接头,用于抗体-药物偶联物(ADC)的合成。体内研究
ADC由通过ADC接头连接ADC细胞毒素的抗体组成。生物活性
Fmoc-3VVD-OH 是一种可降解 (non-cleavable) 的 ADC 连接桥,用于抗体药物结合物 (ADCs) 的合成。靶点
Cleavable
|
体外研究
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.