866893-90-5
866893-90-5 结构式
基本信息
Aftin-4 >=98% (HPLC)
AFTIN-4
AFTIN 4
AFTIN4
N6-methyl-(R)-roscovitine
1-Butanol, 2-[[9-(1-methylethyl)-6-[methyl(phenylmethyl)amino]-9H-purin-2-yl]amino]-, (2R)-
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/05/22 | HY-111267 | 866893-90-5 Aftin-4 | 866893-90-5 | 2mg | 729元 |
| 2025/05/22 | HY-111267 | 866893-90-5 Aftin-4 | 866893-90-5 | 10mM * 1mLin DMSO | 1054元 |
| 2025/05/22 | HY-111267 | 866893-90-5 Aftin-4 | 866893-90-5 | 5mg | 1245元 |
常见问题列表
Amyloid-β
Aftin-4 selectively and potently increases Aβ 1-42 in N2a cells, primary neurons, and brain lysates, with an EC 50 value around 30 μM.
Aftin-4 increases Aβ 1-42 levels in vivo in mice and provokes rapidly a sustained toxicity highly reminiscent of Alzheimer’s disease (AD). Aftin-4 is administered at increasing doses, between 3 and 20 nmol/mouse, into the lateral ventricle and animals are sacrificed at various time points, between 3 to 14 days after injection. The hippocampus is dissected out the contents in Aβ 1-40 or Aβ 1-42 is determined using a mouse ELISA assay. Aftin-4 dose-dependently and significantly increases Aβ 1-42 content, up to +216% at the highest dose tested.