870677-05-7
870677-05-7 结构式
基本信息
中文别名
化合物DMAPT 英文别名
DMAPTDimethylamino Parthenolide
UJNSFDHVIBGEJZ-KVUCBBCISA-N
NF-κB,Inhibitor,Nuclear factor-κB,inhibit,DMAPT,Nuclear factor-kappaB
(1S,2R,4R,7~{Z},11S,12S)-12-[(dimethylamino)methyl]-4,8-dimethyl-3,14-dioxatricyclo[9.3.0.0^{2,4}]tetradec-7-en-13-one
Oxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one, 8-[(dimethylamino)methyl]-2,3,6,7,7a,8,10a,10b-octahydro-1a,5-dimethyl-, (1aR,4E,7aS,8S,10aS,10bR)-
物理化学性质
储存条件-20°C
溶解度Soluble in DMSO, Ethyl acetate, or Ethanol.
形态solid
颜色White
稳定性Stable for 2 years from date of purchase as supplied. Solutions in DMSO, ethanol, or ethyl acetate may be stored at -20° for up to 1 month.
InChIKeyUJNSFDHVIBGEJZ-SQJADDCJSA-N
SMILESC/C1=C\CC[C@](O2)(C)[C@@]2([H])[C@@H](OC([C@@H]3CN(C)C)=O)[C@@]3([H])CC1
常见问题列表
概述
(S)-DMAPT (Dimethylamino Parthenolide) 是Parthenolide (PTL) 的类似物，是具有口服活性的 NF-κB 抑制剂，对原发性急性髓性白血病细胞的LD50 值为1.7 μM。具有潜在的抗肿瘤和抗转移作用。