90-18-6

中文名称六羟黄酮/栎草亭

英文名称 3,3',4',5,6,7-HEXAHYDROXYFLAVONE

CAS 90-18-6

分子式 C15H10O8

分子量 318.24

MOL 文件 90-18-6.mol

更新日期 2025/10/28 14:49:03

90-18-6 结构式

基本信息物理化学性质图谱信息六羟黄酮/栎草亭价格(试剂级) 常见问题列表

基本信息

中文别名

栎草亭
六羟黄酮/栎草亭
槲皮万寿菊素栎草亭
栎草亭,槲皮万寿菊素
3,3',4',5,6,7-六羟基黄酮

英文别名

QUERCETAGIN
QUERCETAGETIN
QUERCETAGENIN
6-Hydroxyquercetin
6,7,4'-Quercetagetin
QUEBRACHITOL, (-)-(RG)
Quercetagetin 7-glucoside
3,5,6,7,3',4'-HEXAHYDROXYFLAVONE
3,3',4',5,6,7-HEXAHYDROXYFLAVONE
QuercetagitrinQuercetagetin 7-glucoside

所属类别

生物化工：提取物

物理化学性质

外观性状来源于万寿菊

熔点>300°C

沸点732.4±60.0 °C(Predicted)

密度1.912±0.06 g/cm3(Predicted)

储存条件-20°C储存

溶解度DMSO : 125 mg/mL (392.79 mM; Need ultrasonic)

酸度系数(pKa)6.12±0.40(Predicted)

形态结晶固体

颜色Light yellow to yellow

InChIInChI=1S/C15H10O8/c16-6-2-1-5(3-7(6)17)15-14(22)13(21)10-9(23-15)4-8(18)11(19)12(10)20/h1-4,16-20,22H

InChIKeyZVOLCUVKHLEPEV-UHFFFAOYSA-N

SMILESC1(C2=CC=C(O)C(O)=C2)OC2=CC(O)=C(O)C(O)=C2C(=O)C=1O

LogP2.230 (est)

图谱信息

六羟黄酮/栎草亭(90-18-6)核磁图(¹HNMR)

六羟黄酮/栎草亭价格(试剂级)

报价日期	产品编号	产品名称	CAS号	包装	价格
2025/05/22	HY-N4149	六羟黄酮/栎草亭 Quercetagetin	90-18-6	1 mg	990元
2025/05/22	HY-N4149	六羟黄酮/栎草亭 Quercetagetin	90-18-6	5mg	2100元
2025/05/22	HY-N4149	六羟黄酮/栎草亭 Quercetagetin	90-18-6	10mM * 1mLin DMSO	2310元

常见问题列表

生物活性

Quercetagetin (6-Hydroxyquercetin) 是从 Citrus unshiu (C. unshiu) 果皮中分离的主要类黄酮。Quercetagetin 是一种中等强度和选择性的，细胞渗透性的 pim-1 激酶抑制，IC50 为 0.34 μM。具有抗炎和抗肿瘤活性。

靶点

PIM1

0.34 μM (IC ₅₀ )

PIM2

3.45 μM (IC ₅₀ )

RSK2

2.82 μM (IC ₅₀ )

PKA

21.2 μM (IC ₅₀ )

体外研究

Quercetagetin also inhibits PIM2, PKA, and RSK2 with IC ₅₀ s of 3.45, 21.2, and 2.82 µM, respectively.
Quercetagetin (0.1, 1, 10, and 100 μM, 72 hours) inhibits growth of RWPE2 prostate cancer cells with average ED ₅₀ is 3.8 μM.

Cell Viability Assay

Cell Line:	RWPE2 prostate cancer cells
Concentration:	0.1, 1, 10, and 100 μM
Incubation Time:	72 hours
Result:	Inhibited growth of RWPE2 prostate cancer cells with average ED ₅₀ is 3.8 μM.

体内研究

Quercetagetin significantly inhibits UVB-induced skin cancer development. Topical application of 4 or 20 nmol of Quercetagetin to mouse skin reduces tumor incidence by 32.0% and 46.7%, respectively.

Animal Model:	SKH-1 hairless mice model
Dosage:	4 or 20 nmol
Administration:	Topical application; 28 weeks
Result:	Inhibited UVB-induced skin tumorigenesis in SKH-1 hairless mice models. Delayed the development of tumors and reduced tumor volumes in an SKH-1 hairless mice model.