901787-88-0
中文名称
(Z)-4EGI-1
英文名称
OTAVA-BB 7070707011
CAS
901787-88-0
分子式
C18H12Cl2N4O4S
分子量
451.28
MOL 文件
901787-88-0.mol
901787-88-0 结构式
物理化学性质
沸点668.9±65.0 °C(Predicted)
密度1.58±0.1 g/cm3(Predicted)
储存条件-20°C储存
溶解度DMSO: 50 mg/mL (110.80 mM; ultrasonic and warming and heat to 60°C)
酸度系数(pKa)0.71±0.41(Predicted)
形态Solid
颜色Light brown to gray
(Z)-4EGI-1价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/02/08 | HY-19831A | (Z)-4EGI-1 | 901787-88-0 | 1 mg | 391元 |
| 2025/02/08 | HY-19831A | (Z)-4EGI-1 | 901787-88-0 | 5mg | 990元 |
| 2025/02/08 | HY-19831A | (Z)-4EGI-1 | 901787-88-0 | 10mM * 1mLin DMSO | 1089元 |
常见问题列表
生物活性
(Z)-4EGI-1 是 4EGI-1 的 Z-型异构体，是 eIF4E/eIF4G 相互作用和翻译起始的抑制剂。(Z)-4EGI-1 有效结合 eIF4E ，IC50 为 43.5 μM，Kd 值为 8.74 μM。(Z)-4EGI-1 具有抗癌活性。靶点
IC50: 43.5 μM (eIF4E)
Kd: 8.74 μM (eIF4E)
体外研究
(Z)-4EGI-1 (15-30 µM; 6 hours; CRL-2813 melanoma cells) treatment markedly reduces the expressions of the regulatory proteins: cyclin D1, cyclin E, and Survivin, while the expressions of housekeeping proteins such as β-Actin and α-Tubulin are not affected.
(Z)-4EGI-1 inhibits cancer cells proliferation with IC
50
values of 15.3 μM and 11.6 μM for CRL-2351 breast cells and CRL-2813 melanoma cells, respectively.
Western Blot Analysis
| Cell Line: | CRL-2813 melanoma cells |
| Concentration: | 15 µM, 30 µM |
| Incubation Time: | 6 hours |
| Result: | Markedly reduced the expressions of the regulatory proteins: cyclin D1, cyclin E, and Survivin. |