924377-85-5
中文名称
1,3-Dihydro-1-[1-[(5,6,7,8-tetrahydro-4H-cyclohepta[b]thien-2-yl)carbonyl]-4-piperidinyl]-2H-benzimidazol-2-one
英文名称
1,3-Dihydro-1-[1-[(5,6,7,8-tetrahydro-4H-cyclohepta[b]thien-2-yl)carbonyl]-4-piperidinyl]-2H-benzimidazol-2-one
CAS
924377-85-5
分子式
C22H25N3O2S
分子量
395.52
MOL 文件
924377-85-5.mol
924377-85-5 结构式
基本信息
中文别名
化合物 T15425 英文别名
GSK 1702934A1,3-Dihydro-1-[1-[(5,6,7,8-tetrahydro-4H-cyclohepta[b]thien-2-yl)carbonyl]-4-piperidinyl]-2H-benzimidazol-2-one
物理化学性质
密度1.299±0.06 g/cm3(Predicted)
储存条件RT
溶解度溶于DMSO（最高50mg/ml）或乙醇（加热最高25mg/ml）
酸度系数(pKa)11.98±0.30(Predicted)
形态固体
颜色白色
稳定性可在-20°C下的DMSO或乙醇溶液保存长达2个月。
常见问题列表
生物活性
GSK1702934A是一种选择性的 TRPC3 激动剂。GSK1702934A 通过激活 TRPC3 调节心脏收缩力和心律失常。靶点
|
TRPC3
|
体外研究
GSK1702934A is able to induce TRPC3/6-currents in HEK293 cells transduced with recombinant human TRPC3/6 with an EC
50
of 0.08 mM and 0.44 mM, respectively.
GSK1702934A induces a transient, non-selective conductance and prolonged action potentials in TRPC3-overexpressing myocytes but not in wild-type myocytes.
GSK1702934A substantially promotes NCX currents in TRPC3-overexpressing myocytes.
体内研究
GSK1702934A (0.3-3 mg/kg; i.v.) transiently increases blood pressure by 15 ~ 35 mmHg in conscious Sprague Dawley rats.