94367-21-2
中文名称
N-琥珀酰基-亮氨酰-亮氨酰-缬氨酰-酪氨酸-7-胺基-4-甲基香豆素
英文名称
SUC-LEU-LEU-VAL-TYR-AMC
CAS
94367-21-2
分子式
C40H53N5O10
分子量
763.88
MOL 文件
94367-21-2.mol
更新日期
2025/05/18 15:29:42
94367-21-2 结构式
基本信息
中文别名
蛋白酶体20S荧光底物SUC-LLVY-AMCN-琥珀酰-LEU-LEU-VAL-TYR-7-氨基-4-甲基香豆素
N-琥珀酰基-亮氨酰-亮氨酰-缬氨酰-酪氨酸-7-胺基-4-甲基香豆素
英文别名
Z-LLVY-AMCSUC-LLVY-AMC
SUC-LEU-LEU-VAL-TYR-MCA
SUC-LEU-LEU-VAL-TYR-AMC
CALPAIN SUBSTRATE (FLUOROGENIC)
SUC-LEU-LEU-VAL-TYR-AMC USP/EP/BP
PROTEASOME SUBSTRATE III (FLUOROGENIC)
CHYMOTRYPSIN SUBSTRATE III, FLUOROGENIC
PROTEASOME 20S, (SUC-LEU-LEU-VAL-TYR-AMC)
SUC-LEU-LEU-VAL-TYR-7-AMINO-4-METHYLCOUMARIN
所属类别
生物化工：酪氨酸类衍生物物理化学性质
沸点1116.8±65.0 °C(Predicted)
密度1.249±0.06 g/cm3(Predicted)
储存条件-20°C
溶解度可溶于DMSO（高达20mg/ml）或DMF（高达10mg/ml）
酸度系数(pKa)4.69±0.10(Predicted)
形态冻干固体
颜色白色至灰白色
水溶解性0.1% trifluoroacetic acid in acetonitrile: water (3:1): 1mg/mL, clear, colorless
序列Suc-Leu-Leu-Val-Tyr-AMC
稳定性Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 1 month.
Suc-Leu-Leu-Val-Tyr-AMC价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/02/08 | HY-P1002 | N-琥珀酰基-亮氨酰-亮氨酰-缬氨酰-酪氨酸-7-胺基-4-甲基香豆素 Suc-Leu-Leu-Val-Tyr-AMC | 94367-21-2 | 1mg | 660元 |
| 2025/02/08 | HY-P1002 | N-琥珀酰基-亮氨酰-亮氨酰-缬氨酰-酪氨酸-7-胺基-4-甲基香豆素 Suc-Leu-Leu-Val-Tyr-AMC | 94367-21-2 | 5mg | 1300元 |
| 2025/02/08 | HY-P1002 | Suc-Leu-Leu-Val-Tyr-AMC | 94367-21-2 | 10 mg | 2210元 |
常见问题列表
生物活性
Suc-Leu-Leu-Val-Tyr-AMC 是一种荧光底物。体外研究
Suc-Leu-Leu-Val-Tyr-AMC (Suc-LLVY) is a membrane-permeable calpain-specific fluorogenic substrate, pteolytic hydrolysis of the peptidyl-7-amino bond liberates the highly fluorescent 7-amino-4-methylcoumarin (AMC) moiety. The effect of TGF-β on hydrolysis of these substrates (e.g Suc-Leu-Leu-Val-Tyr-AMC) are assessed. Biliary epithelial H69 cells are incubated with 10, 1, 0.1, or 0 ng/mL TGF-β for 24 h. Substrate hydrolysis is then fluorometrically assessed in cytosolic extracts. Basal activity is 1.12, 8.33, and 14.52 nmol AMC/mg protein/min for suc-LLVY-AMC, z-LLE-AMC, and z-LLL-AMC hydrolysis, respectively.