96744-75-1
96744-75-1 结构式
基本信息
中文别名
化合物 T29032N-甲基-N-[(5R,7S,8S)-7-(1-吡咯烷基)-1-氧杂螺[4.5]癸-8-基]苯乙酰胺
(+)-(5Α,7Α,8Β)-N-甲基-N-[7-(1-吡咯烷基)-1-氧螺[4.5]十二-8-基]-苯乙酰胺
(+)-(5Α,7Α,8Β)-N-甲基-N-[7-(1-吡咯烷基)-1-氧螺[4.5]十二-8-基]-苯乙酰胺
英文别名
U-69593U-69593 SELECTIVE K OPIOID AG
N-Methyl-N-(7-(1-pyrrolidinyl)-1-oxaspiro(4,5)dec-8-yl)benzeneacetamide
N-Methyl-N-[(5R,7S,8S)-7-(1-pyrrolidinyl)-1-oxaspiro[4.5]dec-8-yl]benzeneacetamide
Benzeneacetamide, N-methyl-N-((5R,7S,8S)-7-(1-pyrrolidinyl)-1-oxaspiro(4.5)dec-8-yl)-
(5A,7A,8B)-(-)-N-METHYL-(7-(1-PYRROLIDINYL)-1-OXASPIRO (4.5)DEC-8- YL)BENZENEACETAMIDE)
U69593, (+)-(5α,7α,8β)-N-Methyl-N-[7-(1-pyrrolidinyl)-1-oxaspiro[4.5]dec-8-yl]-benzeneacetamide
(5ALPHA,7ALPHA,8BETA)-(+)-N-METHYL-N-(7-[1-PYRROLIDINYL]-1-OXASPIRO[4.5]DEC-8-YL)-BENZENEACETAMIDE
(+)-(5ALPHA,7ALPHA,8BETA)-N-METHYL-N-[7-(1-PYRROLIDINYL)-1-OXASPIRO[4.5]DEC-8-YL]-BENZENEACETAMIDE
Benzeneacetamide, N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspiro(4.5)dec-8-yl)-, (5alpha,7alpha,8beta)-(-)-
物理化学性质
熔点120-123℃
沸点518.7±50.0 °C(Predicted)
密度1.13
RTECS号CY1490060
储存条件2-8°C
溶解度H2O: 14 mg/mL
酸度系数(pKa)9.15±0.20(Predicted)
形态固体
颜色白色
旋光度 (Optical Rotation)[α]/D +7.8°, c = 0.825 in methanol(lit.)
水溶解性45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 10mg/mL
0.1 M HCl: >40mg/mL
ethanol: >40mg/mL
0.1 M NaOH: insoluble
H2O: insoluble
0.1 M HCl: >40mg/mL
ethanol: >40mg/mL
0.1 M NaOH: insoluble
H2O: insoluble
常见问题列表
概述
U-69593 是一种有效且选择性的 κ1阿片受体 激动剂。U-69593 减弱成瘾剂诱导的大鼠行为敏化作用。U-69593 可减轻小鼠的焦虑并增强自发交替记忆。U-69593 降低腹侧纹状体中多巴胺和谷氨酸的钙依赖性透析液水平 [4]。