克力托辛
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- CAS号:
- 105798-74-1
- 英文名:
- clitocine
- 英文别名:
- clitocine;N-(6-Amino-5-nitro-4-pyrimidinyl)-β-D-ribofuranosylamine;b-D-RibofuranosylaMine, N-(6-aMino-5-nitro-4-pyriMidinyl)-;N-(6-Amino-5-nitro-4-pyrimidinyl)-beta-D-ribofuranosylamine;β-D-Ribofuranosylamine, N-(6-amino-5-nitro-4-
pyrimidinyl)-;N-?(6-?amino-?5-?nitro-?4-?pyrimidinyl)?-β-?D-?Ribofuranosylamine
- 中文名:
- 克力托辛
- 中文别名:
- 克力托辛;倒垂杯伞菌素;化合物 T30969
- CBNumber:
- CB01359969
- 分子式:
- C9H13N5O6
- 分子量:
- 287.231
- MOL File:
- 105798-74-1.mol
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克力托辛化学性质
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形态:
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Solid
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颜色:
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White to off-white
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克力托辛性质、用途与生产工艺
Clitocine 是一种来源于蘑菇的腺苷核苷类似物，是一种有效的通读剂 (readthrough)。Clitocine 作为一种无义突变 (nonsense mutations) 的抑制剂，可诱导携带 p53 无义突变等位基因的细胞产生 p53 蛋白。Clitocine 可通过靶向 Mcl-1 诱导多药耐药肿瘤细胞凋亡。具有抗癌活性。
Clitocine incorporation into mRNA is required for premature stop codon readthrough activity, and the presence of clitocine at the third position of a premature stop codon is sufficient to promote robust readthrough.
Clitocine (0-0.8 μM; 24 hours) enhances TRAIL-lethality in in LS411N and SW620 cells. Clitocine (0.2μM; 36 hours) significantly potentiates TRAIL-mediated apoptosis.
Citocine (0.3-3 mg/kg; s.c.; five times per week)-induced p53 inhibits CAOV-33
p53-UAA136
tumor growth in a xenograft model.
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Animal Model:
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nu/nu mice (CAOV-3p53-UAA136 xenograft tumors)
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Dosage:
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0.3, 3 mg/kg (or 20 mg/kg once per week)
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Administration:
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S.c.; five times per week
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Result:
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CAOV-33
p53-UAA136
tumor growth was inhibited.
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克力托辛
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下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2025/02/08 | HY-118341 | 克力托辛
Clitocine | 105798-74-1 | 1 mg | 1818元 |
| 2025/02/08 | HY-118341 | 克力托辛
Clitocine | 105798-74-1 | 5mg | 4000元 |
105798-74-1, 克力托辛 相关搜索:
- 抑制剂
- C9H13N5O6
- 倒垂杯伞菌素
- 化合物 T30969
- 克力托辛
- 105798-74-1
- N-?(6-?amino-?5-?nitro-?4-?pyrimidinyl)?-β-?D-?Ribofuranosylamine
- N-(6-Amino-5-nitro-4-pyrimidinyl)-β-D-ribofuranosylamine
- N-(6-Amino-5-nitro-4-pyrimidinyl)-beta-D-ribofuranosylamine
- β-D-Ribofuranosylamine, N-(6-amino-5-nitro-4-
pyrimidinyl)-
- b-D-RibofuranosylaMine, N-(6-aMino-5-nitro-4-pyriMidinyl)-
- clitocine