833481-73-5
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- CAS号:
- 833481-73-5
- 英文名:
- 2OH-BNPP1
- 英文别名:
- 2OH-BNNP;2OH-BNPP1;2OH-BNPP1 ，S3522;2OH-BNPP1, 10 mM in DMSO;inhibit,2OH BNPP1,2OH-BNPP-1,Inhibitor,2OHBNPP1,2OH-BNPP1;2-((4-Amino-1-(tert-butyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)methyl)phenol;Phenol, 2-[[4-amino-1-(1,1-dimethylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]methyl]-
- 中文名:
- 833481-73-5
- 中文别名:
- 2OH-BNPP1试剂;2OH-BNPP1试剂;化合物2OH-BNPP1;2OH-BNPP1 ,S3522;BUB1KINASE抑制剂(2OH-BNPP1);化合物2OH-BNPP1,10 MM DMSO 溶液;2-((4-氨基-1-(叔丁基)-1H-吡唑并[3,4-d]嘧啶-3-基)甲基)苯酚
- CBNumber:
- CB13110453
- 分子式:
- C16H19N5O
- 分子量:
- 297.36
- MOL File:
- 833481-73-5.mol
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833481-73-5化学性质
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储存条件:
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Store at -20°C
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溶解度:
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DMSO : ≥ 100 mg/mL (336.30 mM)
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形态:
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Solid
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颜色:
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White to off-white
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InChI:
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InChI=1S/C16H19N5O/c1-16(2,3)21-15-13(14(17)18-9-19-15)11(20-21)8-10-6-4-5-7-12(10)22/h4-7,9,22H,8H2,1-3H3,(H2,17,18,19)
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InChIKey:
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LWLCFWPPMNPMOI-UHFFFAOYSA-N
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SMILES:
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C1(O)=CC=CC=C1CC1C2=C(N)N=CN=C2N(C(C)(C)C)N=1
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833481-73-5性质、用途与生产工艺
2OH-BNPP1 是一种 BUB1 kinase 抑制剂，可用于癌症研究。
2OH-BNPP1 (0.1-50 μM) abrogates TGFβ signaling in a dose dependent manner. 2OH-BNPP1 dose-dependently impairs the TGFβ-induced phosphorylation of proteins that mediate canonical and non-canonical TGFβ signaling in multiple cancer cell lines and normal cell lines.
2OH-BNPP1 (50 mg/kg) blocks TGFβ signaling in vivo, and significantly decreases abundance of phosphorylated SMAD2 in tumor-bearing mice.
833481-73-5
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2025/09/19 | S3522 | 833481-73-5
2OH-BNPP1 | 833481-73-5 | 5mg | 2678.84元 |
| 2025/09/19 | S3522 | 833481-73-5
2OH-BNPP1 | 833481-73-5 | 25mg | 8099.97元 |
833481-73-5, 833481-73-5 相关搜索:
- 抑制剂
- 制剂-抑制剂
- 细胞生物学试剂
- 2OH-BNPP1试剂
- 2OH-BNPP1 ,S3522
- 2OH-BNPP1试剂
- 2-((4-氨基-1-(叔丁基)-1H-吡唑并[3,4-d]嘧啶-3-基)甲基)苯酚
- 化合物2OH-BNPP1,10 MM DMSO 溶液
- 化合物2OH-BNPP1
- BUB1KINASE抑制剂(2OH-BNPP1)
- 833481-73-5
- 2OH-BNPP1 ，S3522
- 2OH-BNPP1, 10 mM in DMSO
- inhibit,2OH BNPP1,2OH-BNPP-1,Inhibitor,2OHBNPP1,2OH-BNPP1
- 2OH-BNNP
- Phenol, 2-[[4-amino-1-(1,1-dimethylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]methyl]-
- 2-((4-Amino-1-(tert-butyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)methyl)phenol
- 2OH-BNPP1