ERK-IN-1 (COMPOUND B)
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- CAS号:
- 1715025-32-3
- 英文名:
- ERK-IN-1
- 英文别名:
- ERK-IN-1;Rineterkib;Rineterkib，LTT-462;Rineterkib(ERK-IN-1;Rineterkib free base;ERK-IN-1 (COMPOUND B);Rineterkib, 10 mM in DMSO;Raf,G12V,Rineterkib,Extracellular signal regulated kinases,G12D,ERK,NSCLC,inhibit,G12C,MAPK,KRAS,Raf kinases,Inhibitor;4-{3-amino-6-[(1S,3S,4S)-3-fluoro-4-hydroxycyclohexyl]pyrazin-2-yl}-N-[(1S)-1-(3-bromo-5-fluorophenyl)-2-(methylamino)ethyl]-2-fluorobenzamide;Benzamide, 4-[3-amino-6-[(1S,3S,4S)-3-fluoro-4-hydroxycyclohexyl]-2-pyrazinyl]-N-[(1S)-1-(3-bromo-5-fluorophenyl)-2-(methylamino)ethyl]-2-fluoro-
- 中文名:
- ERK-IN-1 (COMPOUND B)
- 中文别名:
- 化合物 T11224;化合物RINETERKIB;化合物RINETERKIB,10 MM DMSO 溶液
- CBNumber:
- CB15540362
- 分子式:
- C26H27BrF3N5O2
- 分子量:
- 578.42
- MOL File:
- 1715025-32-3.mol
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ERK-IN-1 (COMPOUND B)化学性质
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沸点:
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717.6±60.0 °C(Predicted)
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密度:
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1.52±0.1 g/cm3(Predicted)
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储存条件:
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4°C, away from moisture and light
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溶解度:
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DMSO:0.0(Max Conc. mg/mL);0.0(Max Conc. mM)
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形态:
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Solid
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酸度系数(pKa):
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12.32±0.46(Predicted)
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颜色:
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White to light yellow
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ERK-IN-1 (COMPOUND B)性质、用途与生产工艺
Rineterkib (compound B) 是具有口服活性的 ERK1 和 ERK2 的抑制剂，通过激活 MAPK 通路中的突变来发挥抗增生作用。这种活性与 KRAS-突变型非小细胞肺癌、BRAF-突变型非小细胞肺癌、KRAS-突变型胰腺癌、KRAS -突变型结肠癌以及 KRAS 突变型卵巢癌尤为相关。Rineterkib hydrochloride 也能抑制 RAF。
ERK-IN-1 (COMPOUND B)
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2025/05/22 | HY-114491 | Rineterkib | 1715025-32-3 | 1 mg | 894元 |
| 2025/05/22 | HY-114491 | ERK-IN-1 (COMPOUND B)
Rineterkib | 1715025-32-3 | 5mg | 2680元 |
ERK-IN-1 (COMPOUND B)
生产厂家
1715025-32-3, ERK-IN-1 (COMPOUND B) 相关搜索:
- 抑制剂
- 库存
- 化合物RINETERKIB,10 MM DMSO 溶液
- 化合物RINETERKIB
- 化合物 T11224
- 1715025-32-3
- Rineterkib, 10 mM in DMSO
- 4-{3-amino-6-[(1S,3S,4S)-3-fluoro-4-hydroxycyclohexyl]pyrazin-2-yl}-N-[(1S)-1-(3-bromo-5-fluorophenyl)-2-(methylamino)ethyl]-2-fluorobenzamide
- Rineterkib(ERK-IN-1
- Benzamide, 4-[3-amino-6-[(1S,3S,4S)-3-fluoro-4-hydroxycyclohexyl]-2-pyrazinyl]-N-[(1S)-1-(3-bromo-5-fluorophenyl)-2-(methylamino)ethyl]-2-fluoro-
- Raf,G12V,Rineterkib,Extracellular signal regulated kinases,G12D,ERK,NSCLC,inhibit,G12C,MAPK,KRAS,Raf kinases,Inhibitor
- Rineterkib，LTT-462
- Rineterkib free base
- Rineterkib
- ERK-IN-1
- ERK-IN-1 (COMPOUND B)